Biomarkers for the prediction of early pulmonary embolism related mortality in spontaneous and provoked thrombotic disease.
Clin Chim Acta
; 492: 78-83, 2019 May.
Article
em En
| MEDLINE
| ID: mdl-30768927
ABSTRACT
Factors associated with provoked PE may influence a biomarker's predictive value for the primary outcome. The aim of this study was to investigate the value of BNP, cTnI, CRP and D-Dimer measurements taken soon after hospital admission for the prediction of 30-day PE-caused death in patients with spontaneous versus provoked PE.Data were extracted from a pool of 726 consecutive PE patients enrolled in the multicenter Serbian PE registry. Blood concentrations of BNP, cTnI, CRP and D-dimer were measured during the first 24â¯h of hospitalization. BNP blood level had strong predictive value for the primary outcome in spontaneous PE (c-statistics 0.943, 95% CI 0.882-1.000, pâ¯=â¯.001) and a slightly lower predictive outcome in provoked PE (c-statistics 0.824, 95% CI 0.745-0.902, pâ¯<â¯.001). NRI and IDI showed that none of the markers, when added to BNP, could improve Cox regression prediction models for 30-day PE-related mortality in either the spontaneous or provoked PE group. Blood levels of BNP measured during the first 24â¯h of hospital admission had an excellent predictive value for 30-day PE-related mortality in spontaneous PE and slightly lower predictive value in provoked PE, whereas CRP, cTnI and D-Dimer did not contribute significantly to the predictive value of BNP in either group.
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Base de dados:
MEDLINE
Assunto principal:
Embolia Pulmonar
/
Trombose
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article