Sensitization in Heart Transplantation: Emerging Knowledge: A Scientific Statement From the American Heart Association.
Circulation
; 139(12): e553-e578, 2019 03 19.
Article
em En
| MEDLINE
| ID: mdl-30776902
ABSTRACT
Sensitization, defined as the presence of circulating antibodies, presents challenges for heart transplant recipients and physicians. When present, sensitization can limit a transplantation candidate's access to organs, prolong wait time, and, in some cases, exclude the candidate from heart transplantation altogether. The management of sensitization is not yet standardized, and current therapies have not yielded consistent results. Although current strategies involve antibody suppression and removal with intravenous immunoglobulin, plasmapheresis, and antibody therapy, newer strategies with more specific targets are being investigated.
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Base de dados:
MEDLINE
Assunto principal:
Transplante de Coração
/
Rejeição de Enxerto
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article