Your browser doesn't support javascript.
loading
JAK3 Variant, Immune Signatures, DNA Methylation, and Social Determinants Linked to Survival Racial Disparities in Head and Neck Cancer Patients.
Guerrero-Preston, Rafael; Lawson, Fahcina; Rodriguez-Torres, Sebastian; Noordhuis, Maartje G; Pirini, Francesca; Manuel, Laura; Valle, Blanca L; Hadar, Tal; Rivera, Bianca; Folawiyo, Oluwasina; Baez, Adriana; Marchionni, Luigi; Koch, Wayne M; Westra, William H; Kim, Young J; Eshleman, James R; Sidransky, David.
Afiliação
  • Guerrero-Preston R; Department of Otolaryngology and Head and Neck Surgery, Johns Hopkins University, School of Medicine, Baltimore, Maryland. rafael.guerrero@upr.edu.
  • Lawson F; Department of Obstetrics and Gynecology, University of Puerto Rico, School of Medicine, San Juan, Puerto Rico.
  • Rodriguez-Torres S; Department of Otolaryngology and Head and Neck Surgery, Johns Hopkins University, School of Medicine, Baltimore, Maryland.
  • Noordhuis MG; Department of Otolaryngology and Head and Neck Surgery, Johns Hopkins University, School of Medicine, Baltimore, Maryland.
  • Pirini F; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
  • Manuel L; Department of Otolaryngology and Head and Neck Surgery, Johns Hopkins University, School of Medicine, Baltimore, Maryland.
  • Valle BL; Department of Otorhinolaryngology/Head and Neck Surgery, University of Groningen, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
  • Hadar T; Biosciences Laboratory, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy.
  • Rivera B; Department of Epidemiology and Biostatistics, The University of Texas Health Science Center at San Antonio, San Antonio, Texas.
  • Folawiyo O; Department of Otolaryngology and Head and Neck Surgery, Johns Hopkins University, School of Medicine, Baltimore, Maryland.
  • Baez A; Breast Health Unit, Department of General Surgery, Shaare Zedek Medical Center, Jerusalem, Israel.
  • Marchionni L; Department of Otolaryngology, University of Puerto Rico, School of Medicine, San Juan, Puerto Rico.
  • Koch WM; Department of Otolaryngology and Head and Neck Surgery, Johns Hopkins University, School of Medicine, Baltimore, Maryland.
  • Westra WH; Department of Otolaryngology, University of Puerto Rico, School of Medicine, San Juan, Puerto Rico.
  • Kim YJ; Department of Oncology, Johns Hopkins University, School of Medicine, Baltimore, Maryland.
  • Eshleman JR; Department of Otolaryngology and Head and Neck Surgery, Johns Hopkins University, School of Medicine, Baltimore, Maryland.
  • Sidransky D; Department of Pathology, The Icahn School of Medicine at Mount Sinai Hospital, New York, New York.
Cancer Prev Res (Phila) ; 12(4): 255-270, 2019 04.
Article em En | MEDLINE | ID: mdl-30777857
To inform novel personalized medicine approaches for race and socioeconomic disparities in head and neck cancer, we examined germline and somatic mutations, immune signatures, and epigenetic alterations linked to neighborhood determinants of health in Black and non-Latino White (NLW) patients with head and neck cancer. Cox proportional hazards revealed that Black patients with squamous cell carcinoma of head and neck (HNSCC) with PAX5 (P = 0.06) and PAX1 (P = 0.017) promoter methylation had worse survival than NLW patients, after controlling for education, zipcode, and tumor-node-metastasis stage (n = 118). We also found that promoter methylation of PAX1 and PAX5 (n = 78), was correlated with neighborhood characteristics at the zip-code level (P < 0.05). Analyses also showed differences in the frequency of TP53 mutations (n = 32) and tumor-infiltrating lymphocyte (TIL) counts (n = 24), and the presence of a specific C → A germline mutation in JAK3, chr19:17954215 (protein P132T), in Black patients with HNSCC (n = 73; P < 0.05), when compared with NLW (n = 37) patients. TIL counts are associated (P = 0.035) with long-term (>5 years), when compared with short-term survival (<2 years). We show bio-social determinants of health associated with survival in Black patients with HNSCC, which together with racial differences shown in germline mutations, somatic mutations, and TIL counts, suggests that contextual factors may significantly inform precision oncology services for diverse populations.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Linfócitos do Interstício Tumoral / Mutação em Linhagem Germinativa / Metilação de DNA / Disparidades nos Níveis de Saúde / Janus Quinase 3 / Determinantes Sociais da Saúde / Neoplasias de Cabeça e Pescoço Idioma: En Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Linfócitos do Interstício Tumoral / Mutação em Linhagem Germinativa / Metilação de DNA / Disparidades nos Níveis de Saúde / Janus Quinase 3 / Determinantes Sociais da Saúde / Neoplasias de Cabeça e Pescoço Idioma: En Ano de publicação: 2019 Tipo de documento: Article