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AAV-Mediated Gene Delivery to the Spinal Cord by Intrathecal Injection.
Peterson, Cristina D; Skorput, Alexander G J; Kitto, Kelley F; Wilcox, George L; Vulchanova, Lucy; Fairbanks, Carolyn A.
Afiliação
  • Peterson CD; Department of Neuroscience, University of Minnesota, Minneapolis, MN, USA.
  • Skorput AGJ; Department of Neuroscience, University of Minnesota, Minneapolis, MN, USA.
  • Kitto KF; Department of Neuroscience, University of Minnesota, Minneapolis, MN, USA.
  • Wilcox GL; Department of Neuroscience, University of Minnesota, Minneapolis, MN, USA.
  • Vulchanova L; Department of Pharmacology, University of Minnesota, Minneapolis, MN, USA.
  • Fairbanks CA; Department of Dermatology, University of Minnesota, Minneapolis, MN, USA.
Methods Mol Biol ; 1950: 199-207, 2019.
Article em En | MEDLINE | ID: mdl-30783975
ABSTRACT
Gene therapy targeting the spinal cord is an important tool for analyzing mechanisms of nervous system diseases and the development of gene therapies. Analogous to a lumbar puncture in humans, the rodent spinal cord can be accessed through an efficient, noninvasive injection. Here we describe a method for AAV-mediated gene transfer to cells of the spinal cord by intrathecal injection of small quantities of AAV vector.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Medula Espinal / Técnicas de Transferência de Genes / Dependovirus / Vetores Genéticos Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Medula Espinal / Técnicas de Transferência de Genes / Dependovirus / Vetores Genéticos Idioma: En Ano de publicação: 2019 Tipo de documento: Article