Mass Cytometry Analysis Reveals that Specific Intratumoral CD4<sup>+</sup> T Cell Subsets Correlate with Patient Survival in Follicular Lymphoma.

Yang, Zhi-Zhang; Kim, Hyo Jin; Villasboas, Jose C; Price-Troska, Tammy; Jalali, Shahrzad; Wu, Hongyan; Luchtel, Rebecca A; Polley, Mei-Yin C; Novak, Anne J; Ansell, Stephen M

Mass Cytometry Analysis Reveals that Specific Intratumoral CD4⁺ T Cell Subsets Correlate with Patient Survival in Follicular Lymphoma.

Yang, Zhi-Zhang; Kim, Hyo Jin; Villasboas, Jose C; Price-Troska, Tammy; Jalali, Shahrzad; Wu, Hongyan; Luchtel, Rebecca A; Polley, Mei-Yin C; Novak, Anne J; Ansell, Stephen M.

Afiliação

Yang ZZ; Division of Hematology and Internal Medicine, Mayo Clinic, Rochester, MN, USA. Electronic address: yang.zhizhang@mayo.edu.
Kim HJ; Division of Hematology and Internal Medicine, Mayo Clinic, Rochester, MN, USA.
Villasboas JC; Division of Hematology and Internal Medicine, Mayo Clinic, Rochester, MN, USA.
Price-Troska T; Division of Hematology and Internal Medicine, Mayo Clinic, Rochester, MN, USA.
Jalali S; Division of Hematology and Internal Medicine, Mayo Clinic, Rochester, MN, USA.
Wu H; Department of Immunology, Medical College, China Three Gorges University, Yichang, Hubei, China.
Luchtel RA; Division of Hematology and Internal Medicine, Mayo Clinic, Rochester, MN, USA.
Polley MC; Division of Hematology and Internal Medicine, Mayo Clinic, Rochester, MN, USA.
Novak AJ; Division of Hematology and Internal Medicine, Mayo Clinic, Rochester, MN, USA.
Ansell SM; Division of Hematology and Internal Medicine, Mayo Clinic, Rochester, MN, USA. Electronic address: ansell.stephen@mayo.edu.

Cell Rep ; 26(8): 2178-2193.e3, 2019 02 19.

Article em En | MEDLINE | ID: mdl-30784598

Assuntos

Biomarcadores Tumorais/sangue; Linfócitos T CD4-Positivos/metabolismo; Linfoma Folicular/imunologia; Linfoma Folicular/mortalidade; Microambiente Tumoral; Adulto; Idoso; Idoso de 80 Anos ou mais; Antígenos CD28/genética; Antígenos CD28/metabolismo; Linfócitos T CD4-Positivos/classificação; Linhagem Celular Tumoral; Células Cultivadas; Feminino; Humanos; Linfoma Folicular/sangue; Linfoma Folicular/patologia; Masculino; Pessoa de Meia-Idade; Receptor de Morte Celular Programada 1/genética; Receptor de Morte Celular Programada 1/metabolismo; Membro 7 da Superfamília de Receptores de Fatores de Necrose Tumoral/genética; Membro 7 da Superfamília de Receptores de Fatores de Necrose Tumoral/metabolismo

Palavras-chave

CD27; CD4(+)CD25(+) regulatory T cells; CyTOF; PD-1; co-stimulatory receptor; follicular lymphoma; immune signature; intratumoral CD4(+) T cell; mass cytometry; patient survival

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Linfócitos T CD4-Positivos / Biomarcadores Tumorais / Linfoma Folicular / Microambiente Tumoral Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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