Morelloflavone as a novel inhibitor of mitotic kinesin Eg5.

Ogunwa, Tomisin Happy; Taii, Kenichi; Sadakane, Kei; Kawata, Yuka; Maruta, Shinsaku; Miyanishi, Takayuki

Ogunwa, Tomisin Happy; Taii, Kenichi; Sadakane, Kei; Kawata, Yuka; Maruta, Shinsaku; Miyanishi, Takayuki.

Afiliação

Ogunwa TH; Department of Environmental Studies, Graduate School of Fisheries and Environmental Sciences, Nagasaki University, 1-14 Bunkyo-machi, Nagasaki, Japan.
Taii K; Department of Bioinformatics, Graduate School of Engineering, Soka University, 1-236 Tangi-cho, Hachioji, Tokyo, Japan.
Sadakane K; Department of Bioinformatics, Graduate School of Engineering, Soka University, 1-236 Tangi-cho, Hachioji, Tokyo, Japan.
Kawata Y; Department of Environmental Studies, Graduate School of Fisheries and Environmental Sciences, Nagasaki University, 1-14 Bunkyo-machi, Nagasaki, Japan.
Maruta S; Department of Bioinformatics, Graduate School of Engineering, Soka University, 1-236 Tangi-cho, Hachioji, Tokyo, Japan.
Miyanishi T; Department of Environmental Studies, Graduate School of Fisheries and Environmental Sciences, Nagasaki University, 1-14 Bunkyo-machi, Nagasaki, Japan.

J Biochem ; 166(2): 129-137, 2019 Aug 01.

Article em En | MEDLINE | ID: mdl-30785183

Assuntos

Biflavonoides/farmacologia; Inibidores Enzimáticos/farmacologia; Cinesinas/antagonistas & inibidores; Mitose; Biflavonoides/química; Inibidores Enzimáticos/química; Garcinia/química; Humanos; Cinesinas/metabolismo; Modelos Moleculares; Estrutura Molecular; Folhas de Planta/química

Palavras-chave

in silico; biflavonoids; kinesin Eg5; microtubule gliding; morelloflavone

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Cinesinas / Biflavonoides / Inibidores Enzimáticos / Mitose Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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