A Peptide from Kiwifruit Exerts Anti-Inflammatory Effects in Celiac Disease Mucosa.
J Am Coll Nutr
; 38(5): 433-440, 2019 07.
Article
em En
| MEDLINE
| ID: mdl-30794064
ABSTRACT
Objective:
Celiac disease is an immune-mediated disease of the intestine triggered by gluten. Gluten elicits, in genetically susceptible individuals, cytokine responses that are then transmitted to the immunocompetent cells. Vegetables and fruit have anti-inflammatory and antioxidant properties with a protective effect on intestinal epithelium. Kiwifruit is known to have beneficial effects on the intestinal tissues, and it is the only plant food containing the peptide kissper, with anti-inflammatory properties. The aim of this study was the evaluation of the kissper effect on the gluten-induced inflammation in celiac disease.Methods:
We used an in vitro model of intestinal culture explant from celiac disease patients and non-celiac disease patients, cultured for 24 hours with the toxic gliadin peptide P31-43 and kissper preincubation.Results:
Our data showed HLA-DR and TG2 reduction in the celiac disease mucosa pretreated with kissper, as well as a reduction of COX-2 in two patients. No differences we observed for the TGF-b1 and IL-15 levels in supernatants upon kissper pretreatment.Conclusions:
The preliminary results suggest that kissper has a potential anti-inflammatory role in celiac disease.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Peptídeos
/
Proteínas de Plantas
/
Doença Celíaca
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Actinidia
/
Frutas
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Anti-Inflamatórios
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article