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Phase I/II Trial of Liver-derived Mesenchymal Stem Cells in Pediatric Liver-based Metabolic Disorders: A Prospective, Open Label, Multicenter, Partially Randomized, Safety Study of One Cycle of Heterologous Human Adult Liver-derived Progenitor Cells (HepaStem) in Urea Cycle Disorders and Crigler-Najjar Syndrome Patients.
Smets, Françoise; Dobbelaere, Dries; McKiernan, Patrick; Dionisi-Vici, Carlo; Broué, Pierre; Jacquemin, Emmanuel; Lopes, Ana Isabel; Gonçalves, Isabel; Mandel, Hanna; Pawlowska, Joanna; Kaminska, Diana; Shteyer, Eyal; Torre, Giuliano; Shapiro, Riki; Eyskens, François; Clapuyt, Philippe; Gissen, Paul; Pariente, Danièle; Grunewald, Stephanie; Yudkoff, Marc; Binda, Maria Mercedes; Najimi, Mustapha; Belmonte, Nathalie; de Vos, Beatrice; Thonnard, Joelle; Sokal, Etienne.
Afiliação
  • Smets F; Department of Paediatrics, Paediatric Gastroenterology and Hepatology Unit, Cliniques Universitaires St Luc, Université Catholique de Louvain, Brussels, Belgium.
  • Dobbelaere D; Medical Reference Center for Inherited Metabolic Diseases, University Children's Hospital Jeanne de Flandre and RADEME Research Team for Rare Metabolic and Developmental Diseases, EA 7364, University Lille 2, CHRU Lille, Lille, France.
  • McKiernan P; Liver Unit, Birmingham Children's Hospital, Birmingham, United Kingdom.
  • Dionisi-Vici C; Department of Hepatology, Gastroenterology and Nutrition, Ospedale Pediatrico Bambino Gesù di Roma, Roma, Italy.
  • Broué P; Hépatologie pédiatrique et maladies héréditaires du métabolisme, Centre de compétences maladies héréditaires du métabolisme, Hôpital des enfants, CHU Toulouse, France.
  • Jacquemin E; Pediatric Hepatology and Liver Transplantation Unit, Reference Centre for Rare Liver Diseases, CHU Bicêtre, Assistance Publique, Hôpitaux de Paris, DHU Hepatinov, INSERM 1174, University Paris Sud, Paris, France.
  • Lopes AI; Department of Pediatrics, Gastroenterology Unit, Medical Faculty of Lisbon, University Hospital Santa Maria, Lisbon, Portugal.
  • Gonçalves I; Hospital Pediátrico de Coimbra, Centro Hospitalar da Universidade de Coimbra, Coimbra, Portugal.
  • Mandel H; Department of Pediatrics, Metabolic Unit, Rambam Medical Center, Meyer Children's Hospital, Haifa, Israel.
  • Pawlowska J; Department of Gastroenterology, Hepatology and Nutritional Disorders, The Children's Memorial Health Institute, Warsaw, Poland.
  • Kaminska D; Department of Gastroenterology, Hepatology and Nutritional Disorders, The Children's Memorial Health Institute, Warsaw, Poland.
  • Shteyer E; Department of Pediatrics, Hadassah Ein-Kerem Medical Center, Jerusalem, Israel.
  • Torre G; Department of Hepatology, Gastroenterology and Nutrition, Ospedale Pediatrico Bambino Gesù di Roma, Roma, Italy.
  • Shapiro R; Liver Transplantation Unit, Institute of Gastroenterology, Schneider Children's Medical Center of Israel, Petach Tikva, Israel.
  • Eyskens F; Paediatric department, Universitair Ziekenhuis Antwerpen, Edegem, Belgium.
  • Clapuyt P; Department of Radiology, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium.
  • Gissen P; GOSH UCL Biomedical Center, UCL Great Ormond Street Institute of Child Health, London, United Kingdom.
  • Pariente D; Department of Radiology, CHU Bicêtre, Le Kremlin Bicêtre, France.
  • Grunewald S; Centre for Inborn Errors of Metabolism, Great Ormond Street Hospital and Institute of Child Health, UCL, London, United Kingdom.
  • Yudkoff M; Mass Spectroscopy Center, The Children's Hospital of Philadelphia, Philadelphia, USA.
  • Binda MM; Promethera Biosciences, Mont-Saint-Guibert, Belgium.
  • Najimi M; Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain, Brussels, Belgium.
  • Belmonte N; Promethera Biosciences, Mont-Saint-Guibert, Belgium.
  • de Vos B; Promethera Biosciences, Mont-Saint-Guibert, Belgium.
  • Thonnard J; Promethera Biosciences, Mont-Saint-Guibert, Belgium.
  • Sokal E; Promethera Biosciences, Mont-Saint-Guibert, Belgium.
Transplantation ; 103(9): 1903-1915, 2019 09.
Article em En | MEDLINE | ID: mdl-30801523

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transplante de Fígado / Síndrome de Crigler-Najjar / Transplante de Células-Tronco / Distúrbios Congênitos do Ciclo da Ureia / Fígado Idioma: En Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transplante de Fígado / Síndrome de Crigler-Najjar / Transplante de Células-Tronco / Distúrbios Congênitos do Ciclo da Ureia / Fígado Idioma: En Ano de publicação: 2019 Tipo de documento: Article