Autologous nanofat transplantation accelerates foot wound healing in diabetic rats.
Regen Med
; 14(3): 231-241, 2019 03.
Article
em En
| MEDLINE
| ID: mdl-30810491
ABSTRACT
Aim:
This study explored the effects of local transplantation of autologous nanofat in the treatment of rats with diabetic foot wounds. Materials &methods:
Nanofat was transplanted into the left foot wound of diabetic rats. Phosphate-buffered saline injection in the right served as control. We measured wound size, the extent of epithelization, microvessel density and the expression levels of cytokines at six different time-points postoperation.Results:
Compared with the control feet, nanofat-treated feet had significantly smaller wound areas at 7 and 9 days after grafting and showed better re-epithelialization, a greater number of microvessels and higher levels of angiogenic factor expression.Conclusion:
This research shows that autologous nanofat transplantation can promote diabetic foot wound healing in rats.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Cicatrização
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Tecido Adiposo
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Pé Diabético
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Transplante de Células-Tronco
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Diabetes Mellitus Experimental
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article