Mechanisms of PKC-Mediated Enhancement of HIF-1&#945; Activity and its Inhibition by Vitamin K2 in Hepatocellular Carcinoma Cells.

Xia, Jinghe; Ozaki, Iwata; Matsuhashi, Sachiko; Kuwashiro, Takuya; Takahashi, Hirokazu; Anzai, Keizo; Mizuta, Toshihiko

Mechanisms of PKC-Mediated Enhancement of HIF-1α Activity and its Inhibition by Vitamin K2 in Hepatocellular Carcinoma Cells.

Xia, Jinghe; Ozaki, Iwata; Matsuhashi, Sachiko; Kuwashiro, Takuya; Takahashi, Hirokazu; Anzai, Keizo; Mizuta, Toshihiko.

Afiliação

Xia J; Department of Internal Medicine, Saga Medical School, Saga University, 5-1-1 Nabeshima, Saga 849-8501, Japan. xiajinghe@hotmail.com.
Ozaki I; Department of Internal Medicine, Saga Medical School, Saga University, 5-1-1 Nabeshima, Saga 849-8501, Japan. ozaki@cc.saga-u.ac.jp.
Matsuhashi S; Health Administration Center, Saga Medical School, Saga University, 5-1-1 Nabeshima, Saga 849-8501, Japan. ozaki@cc.saga-u.ac.jp.
Kuwashiro T; Department of Internal Medicine, Saga Medical School, Saga University, 5-1-1 Nabeshima, Saga 849-8501, Japan. matsuha2@edu.cc.saga-u.ac.jp.
Takahashi H; Department of Internal Medicine, Saga Medical School, Saga University, 5-1-1 Nabeshima, Saga 849-8501, Japan. hepatology0321@gmail.com.
Anzai K; Department of Internal Medicine, Saga Medical School, Saga University, 5-1-1 Nabeshima, Saga 849-8501, Japan. hepatology28@msn.com.
Mizuta T; Department of Internal Medicine, Saga Medical School, Saga University, 5-1-1 Nabeshima, Saga 849-8501, Japan. akeizo0479@gmail.com.

Int J Mol Sci ; 20(5)2019 Feb 26.

Article em En | MEDLINE | ID: mdl-30813635

Assuntos

Carcinoma Hepatocelular/patologia; Subunidade alfa do Fator 1 Induzível por Hipóxia/metabolismo; Neoplasias Hepáticas/patologia; Proteína Quinase C/metabolismo; Vitamina K 2/farmacologia; Hipóxia Celular/efeitos dos fármacos; Linhagem Celular Tumoral; Núcleo Celular/metabolismo; Técnicas de Silenciamento de Genes; Humanos; Isoenzimas/metabolismo; Regiões Promotoras Genéticas/genética; Transporte Proteico; Acetato de Tetradecanoilforbol/farmacologia; Fator A de Crescimento do Endotélio Vascular/genética

Palavras-chave

Hepatocellular carcinoma cells; Hypoxia-inducible factor-1α (HIF-1α); Protein kinase C (PKC); Vitamin K2

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteína Quinase C / Carcinoma Hepatocelular / Vitamina K 2 / Subunidade alfa do Fator 1 Induzível por Hipóxia / Neoplasias Hepáticas Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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