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PIM1 inhibition effectively enhances plerixafor-induced HSC mobilization by counteracting CXCR4 upregulation and blocking CXCL12 secretion.
Müller, Tony Andreas; Pennisi, Sandra; Zwick, Anabel; Decker, Sarah; Klein, Claudius; Rister, Benjamin; Rudorf, Alina; Kissel, Sandra; Follo, Marie; Wäsch, Ralph; Illert, Anna Lena; Pfeifer, Dietmar; Oostendorp, Robert; Waskow, Claudia; Dierks, Christine; Duyster, Justus.
Afiliação
  • Müller TA; Department of Hematology and Oncology, Freiburg University Medical Center, Albert-Ludwigs-University of Freiburg, Hugstetter Str. 55, 79106, Freiburg, Germany.
  • Pennisi S; Department of Hematology and Oncology, Freiburg University Medical Center, Albert-Ludwigs-University of Freiburg, Hugstetter Str. 55, 79106, Freiburg, Germany.
  • Zwick A; Department of Hematology and Oncology, Freiburg University Medical Center, Albert-Ludwigs-University of Freiburg, Hugstetter Str. 55, 79106, Freiburg, Germany.
  • Decker S; Department of Internal Medicine III, Klinikum rechts der Isar, Technical University Munich, Ismaninger Str. 22, 81675, Munich, Germany.
  • Klein C; German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Rister B; Department of Hematology and Oncology, Freiburg University Medical Center, Albert-Ludwigs-University of Freiburg, Hugstetter Str. 55, 79106, Freiburg, Germany.
  • Rudorf A; Department of Hematology and Oncology, Freiburg University Medical Center, Albert-Ludwigs-University of Freiburg, Hugstetter Str. 55, 79106, Freiburg, Germany.
  • Kissel S; Department of Hematology and Oncology, Freiburg University Medical Center, Albert-Ludwigs-University of Freiburg, Hugstetter Str. 55, 79106, Freiburg, Germany.
  • Follo M; Department of Hematology and Oncology, Freiburg University Medical Center, Albert-Ludwigs-University of Freiburg, Hugstetter Str. 55, 79106, Freiburg, Germany.
  • Wäsch R; German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Illert AL; Department of Hematology and Oncology, Freiburg University Medical Center, Albert-Ludwigs-University of Freiburg, Hugstetter Str. 55, 79106, Freiburg, Germany.
  • Pfeifer D; Department of Hematology and Oncology, Freiburg University Medical Center, Albert-Ludwigs-University of Freiburg, Hugstetter Str. 55, 79106, Freiburg, Germany.
  • Oostendorp R; Department of Hematology and Oncology, Freiburg University Medical Center, Albert-Ludwigs-University of Freiburg, Hugstetter Str. 55, 79106, Freiburg, Germany.
  • Waskow C; Department of Hematology and Oncology, Freiburg University Medical Center, Albert-Ludwigs-University of Freiburg, Hugstetter Str. 55, 79106, Freiburg, Germany.
  • Dierks C; German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Duyster J; Department of Hematology and Oncology, Freiburg University Medical Center, Albert-Ludwigs-University of Freiburg, Hugstetter Str. 55, 79106, Freiburg, Germany.
Leukemia ; 33(5): 1296-1301, 2019 05.
Article em En | MEDLINE | ID: mdl-30816332
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Células-Tronco Hematopoéticas / Receptores CXCR4 / Mobilização de Células-Tronco Hematopoéticas / Proteínas Proto-Oncogênicas c-pim-1 / Quimiocina CXCL12 / Compostos Heterocíclicos Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Células-Tronco Hematopoéticas / Receptores CXCR4 / Mobilização de Células-Tronco Hematopoéticas / Proteínas Proto-Oncogênicas c-pim-1 / Quimiocina CXCL12 / Compostos Heterocíclicos Idioma: En Ano de publicação: 2019 Tipo de documento: Article