Inhibition of PDE4 by FCPR16 induces AMPK-dependent autophagy and confers neuroprotection in SH-SY5Y cells and neurons exposed to MPP<sup>+</sup>-induced oxidative insult.

Zhong, Jiahong; Xie, Jinfeng; Xiao, Jiao; Li, Dan; Xu, Bingtian; Wang, Xinyi; Wen, Huizhen; Zhou, Zhongzhen; Cheng, Yufang; Xu, Jiangping; Wang, Haitao

Inhibition of PDE4 by FCPR16 induces AMPK-dependent autophagy and confers neuroprotection in SH-SY5Y cells and neurons exposed to MPP⁺-induced oxidative insult.

Zhong, Jiahong; Xie, Jinfeng; Xiao, Jiao; Li, Dan; Xu, Bingtian; Wang, Xinyi; Wen, Huizhen; Zhou, Zhongzhen; Cheng, Yufang; Xu, Jiangping; Wang, Haitao.

Afiliação

Zhong J; Department of Neuropharmacology and Drug Discovery, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, China.
Xie J; Department of Neuropharmacology and Drug Discovery, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, China.
Xiao J; Department of Neuropharmacology and Drug Discovery, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, China.
Li D; Department of Neuropharmacology and Drug Discovery, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, China.
Xu B; Department of Neuropharmacology and Drug Discovery, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, China; Central Laboratory, Southern Medical University, Guangzhou, 510515, China.
Wang X; Department of Neuropharmacology and Drug Discovery, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, China.
Wen H; Central Laboratory, Southern Medical University, Guangzhou, 510515, China.
Zhou Z; Department of Neuropharmacology and Drug Discovery, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, China.
Cheng Y; Central Laboratory, Southern Medical University, Guangzhou, 510515, China.
Xu J; Department of Neuropharmacology and Drug Discovery, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, China; Central Laboratory, Southern Medical University, Guangzhou, 510515, China; Center for Brian Science and Brain-Inspired Intelligence, Guangdong-Hong Kong-Macao
Wang H; Department of Neuropharmacology and Drug Discovery, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, China; Center for Brian Science and Brain-Inspired Intelligence, Guangdong-Hong Kong-Macao Greater Bay Area, China; Key Laboratory of Mental Health of the Ministry o

Free Radic Biol Med ; 135: 87-101, 2019 05 01.

Article em En | MEDLINE | ID: mdl-30818055

Assuntos

Benzamidas/farmacologia; Nucleotídeo Cíclico Fosfodiesterase do Tipo 4/genética; Doença de Parkinson/tratamento farmacológico; Inibidores da Fosfodiesterase 4/farmacologia; Quinases Proteína-Quinases Ativadas por AMP; Animais; Autofagia/efeitos dos fármacos; Regulação da Expressão Gênica/efeitos dos fármacos; Humanos; Camundongos; Proteínas Associadas aos Microtúbulos/genética; Neurônios/efeitos dos fármacos; Neurônios/patologia; Neuroproteção/genética; Estresse Oxidativo/efeitos dos fármacos; Doença de Parkinson/genética; Doença de Parkinson/patologia; Cultura Primária de Células; Proteínas Quinases/genética; Proteínas de Ligação a RNA/genética; Espécies Reativas de Oxigênio/metabolismo

Palavras-chave

Autophagy; FCPR16; Oxidative insult; PDE4; Parkinson's disease

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Benzamidas / Nucleotídeo Cíclico Fosfodiesterase do Tipo 4 / Inibidores da Fosfodiesterase 4 Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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