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Comparative study of simulated nebulized and spray particle deposition in chronic rhinosinusitis patients.
Farzal, Zainab; Basu, Saikat; Burke, Alyssa; Fasanmade, Olulade O; Lopez, Erin M; Bennett, William D; Ebert, Charles S; Zanation, Adam M; Senior, Brent A; Kimbell, Julia S.
Afiliação
  • Farzal Z; Department of Otolaryngology-Head and Neck Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC.
  • Basu S; Department of Mechanical Engineering, South Dakota State University, Brookings, South Dakota.
  • Burke A; Center for Environmental Medicine, Asthma, and Lung Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC.
  • Fasanmade OO; Department of Otolaryngology-Head and Neck Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC.
  • Lopez EM; Department of Otolaryngology-Head and Neck Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC.
  • Bennett WD; Center for Environmental Medicine, Asthma, and Lung Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC.
  • Ebert CS; Department of Otolaryngology-Head and Neck Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC.
  • Zanation AM; Department of Otolaryngology-Head and Neck Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC.
  • Senior BA; Department of Otolaryngology-Head and Neck Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC.
  • Kimbell JS; Department of Otolaryngology-Head and Neck Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC.
Int Forum Allergy Rhinol ; 9(7): 746-758, 2019 07.
Article em En | MEDLINE | ID: mdl-30821929
ABSTRACT

BACKGROUND:

Topical intranasal drugs are widely prescribed for chronic rhinosinusitis (CRS), although delivery can vary with device type and droplet size. The study objective was to compare nebulized and sprayed droplet deposition in the paranasal sinuses and ostiomeatal complex (OMC) across multiple droplet sizes in CRS patients using computational fluid dynamics (CFD).

METHODS:

Three-dimensional models of sinonasal cavities were constructed from computed tomography (CT) scans of 3 subjects with CRS refractory to medical therapy using imaging software. Assuming steady-state inspiratory airflow at resting rate, CFD was used to simulate 1-µm to 120-µm sprayed droplet deposition in the left and right sinuses and OMC with spray nozzle positioning as in current nasal spray use instructions. Zero-velocity nebulization simulations were performed for 1-µm to 30-µm droplet sizes, maximal sinus and OMC deposition fractions (MSDF) were obtained, and sizes that achieved at least 50% of MSDF were identified. Nebulized MSDF was compared to sprayed droplet deposition. We also validated CFD framework through in vitro experiments.

RESULTS:

Among nebulized droplet sizes, 11-µm to 14-µm droplets achieved at least 50% of MSDF in all 6 sinonasal cavities. Four of 6 sinonasal cavities had greater sinus and OMC deposition with nebulized droplets than with sprayed droplets at optimal sizes.

CONCLUSION:

Nebulized droplets may target the sinuses and OMC more effectively than sprayed particles at sizes achieving best deposition. Further studies are needed to confirm our preliminary findings. Several commercial nasal nebulizers have average particle sizes outside the optimal nebulized droplet size range found here, suggesting potential for product enhancement.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Seios Paranasais / Sinusite / Nebulizadores e Vaporizadores / Rinite / Aerossóis / Modelos Anatômicos Idioma: En Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Seios Paranasais / Sinusite / Nebulizadores e Vaporizadores / Rinite / Aerossóis / Modelos Anatômicos Idioma: En Ano de publicação: 2019 Tipo de documento: Article