Visualizing the Supramolecular Assembly of Collagen.
Methods Mol Biol
; 1952: 33-44, 2019.
Article
em En
| MEDLINE
| ID: mdl-30825163
ABSTRACT
Among biological macromolecules, collagen enjoys quite a peculiar status. Making up as much as a third of the protein fraction of the body it is the main responsible for the functional properties of the extracellular matrix, which can be efficiently tuned and tailored by modifying the length, volume fraction, and spatial layout of its collagen content. The supramolecular aggregates of collagen are therefore subject to be investigation by several viewpoints and at different scales, from the finest interactions of individual collagen molecules to the spatial layout of fibril bundles. As a consequence, no treatise can pretend to be exhaustive about the several techniques that can be useful in different moments and/or for different purposes. So, in this chapter, we focus only on some applications of the transmission electron microscope (TEM), of the scanning electron microscope (SEM), and of the atomic force microscope (AFM).
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Base de dados:
MEDLINE
Assunto principal:
Microscopia Eletrônica de Varredura
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Colágeno
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Microscopia de Força Atômica
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Microscopia Eletrônica de Transmissão
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article