Palladium-Catalyzed Highly Enantioselective Cycloaddition of Vinyl Cyclopropanes with Imines.
Org Lett
; 21(6): 1713-1716, 2019 03 15.
Article
em En
| MEDLINE
| ID: mdl-30829043
ABSTRACT
Palladium-catalyzed asymmetric formal [3 + 2] cycloaddition of vinyl cyclopropanes and aldimines or isatin-derived ketimines proceeded smoothly in the presence of chiral phosphoramidite ligands. The corresponding highly functionalized and optically enriched pyrrolidine or spiro[pyrrolidin-3,2'-oxindole] derivatives are obtained in up to 94% yield and with up to 96% ee and 71 dr.
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MEDLINE
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article