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Palladium-Catalyzed Highly Enantioselective Cycloaddition of Vinyl Cyclopropanes with Imines.
Huang, Xiao-Bing; Li, Xian-Jing; Li, Tian-Tian; Chen, Bo; Chu, Wen-Dao; He, Long; Liu, Quan-Zhong.
Afiliação
  • Huang XB; Chemical Synthesis and Pollution Control Key Laboratory of Sichuan Province, College of Chemistry and Chemical Engineering , China West Normal University , No. 1, Shida Road , Nanchong 637002 , P.R. China.
  • Li XJ; Chemical Synthesis and Pollution Control Key Laboratory of Sichuan Province, College of Chemistry and Chemical Engineering , China West Normal University , No. 1, Shida Road , Nanchong 637002 , P.R. China.
  • Li TT; Chemical Synthesis and Pollution Control Key Laboratory of Sichuan Province, College of Chemistry and Chemical Engineering , China West Normal University , No. 1, Shida Road , Nanchong 637002 , P.R. China.
  • Chen B; Chemical Synthesis and Pollution Control Key Laboratory of Sichuan Province, College of Chemistry and Chemical Engineering , China West Normal University , No. 1, Shida Road , Nanchong 637002 , P.R. China.
  • Chu WD; Chemical Synthesis and Pollution Control Key Laboratory of Sichuan Province, College of Chemistry and Chemical Engineering , China West Normal University , No. 1, Shida Road , Nanchong 637002 , P.R. China.
  • He L; Chemical Synthesis and Pollution Control Key Laboratory of Sichuan Province, College of Chemistry and Chemical Engineering , China West Normal University , No. 1, Shida Road , Nanchong 637002 , P.R. China.
  • Liu QZ; College of Pharmaceutical Sciences , Guizhou University of Chinese Medicine , Guiyang 550025 , P.R. China.
Org Lett ; 21(6): 1713-1716, 2019 03 15.
Article em En | MEDLINE | ID: mdl-30829043
ABSTRACT
Palladium-catalyzed asymmetric formal [3 + 2] cycloaddition of vinyl cyclopropanes and aldimines or isatin-derived ketimines proceeded smoothly in the presence of chiral phosphoramidite ligands. The corresponding highly functionalized and optically enriched pyrrolidine or spiro[pyrrolidin-3,2'-oxindole] derivatives are obtained in up to 94% yield and with up to 96% ee and 71 dr.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2019 Tipo de documento: Article