Formulation and evaluation of cyclodextrin complexes for improved anticancer activity of repurposed drug: Niclosamide.

Lodagekar, Anurag; Borkar, Roshan M; Thatikonda, Sowjanya; Chavan, Rahul B; Naidu, V G M; Shastri, Nalini R; Srinivas, R; Chella, Naveen

Lodagekar, Anurag; Borkar, Roshan M; Thatikonda, Sowjanya; Chavan, Rahul B; Naidu, V G M; Shastri, Nalini R; Srinivas, R; Chella, Naveen.

Afiliação

Lodagekar A; Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, 500037, India.
Borkar RM; National Centre for Mass Spectrometry, CSIR-Indian Institute of Chemical Technology (IICT), Hyderabad, 500007, India.
Thatikonda S; Department of Pharmacology, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, 500037, India.
Chavan RB; Solid State Pharmaceutical Research Group (SSPRG), Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, 500037, India.
Naidu VGM; Department of Pharmacology, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, 500037, India.
Shastri NR; Solid State Pharmaceutical Research Group (SSPRG), Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, 500037, India.
Srinivas R; National Centre for Mass Spectrometry, CSIR-Indian Institute of Chemical Technology (IICT), Hyderabad, 500007, India.
Chella N; Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, 500037, India. Electronic address: naveen.niperhyd@gov.in.

Carbohydr Polym ; 212: 252-259, 2019 May 15.

Article em En | MEDLINE | ID: mdl-30832855

Assuntos

Antineoplásicos/síntese química; Ciclodextrinas/síntese química; Composição de Medicamentos/métodos; Reposicionamento de Medicamentos/métodos; Niclosamida/síntese química; Animais; Anticestoides/síntese química; Anticestoides/metabolismo; Antineoplásicos/metabolismo; Ciclodextrinas/metabolismo; Avaliação Pré-Clínica de Medicamentos/métodos; Células HCT116; Humanos; Masculino; Camundongos; Camundongos Endogâmicos BALB C; Niclosamida/metabolismo

Palavras-chave

Analytical method by LCMS; Bioavailability; Hydroxypropyl-ß-cyclodextrin; Inclusion complex; Molecular modeling

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ciclodextrinas / Composição de Medicamentos / Reposicionamento de Medicamentos / Niclosamida / Antineoplásicos Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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