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ADAM10 in Alzheimer's disease: Pharmacological modulation by natural compounds and its role as a peripheral marker.
Manzine, Patricia Regina; Ettcheto, Miren; Cano, Amanda; Busquets, Oriol; Marcello, Elena; Pelucchi, Silvia; Di Luca, Monica; Endres, Kristina; Olloquequi, Jordi; Camins, Antoni; Cominetti, Márcia Regina.
Afiliação
  • Manzine PR; Department of Gerontology, Federal University of São Carlos, São Carlos, Brazil; Departament de Farmacologia, Toxicologia i Química Terapèutica, Facultat de Farmàcia i Ciències del'Alimentació, Universitat de Barcelona, Barcelona, Spain. Electronic address: patricia_manzine@yahoo.com.br.
  • Ettcheto M; Departament de Farmacologia, Toxicologia i Química Terapèutica, Facultat de Farmàcia i Ciències del'Alimentació, Universitat de Barcelona, Barcelona, Spain; Biomedical Research Networking Centre in Neurodegenerative Diseases (CIBERNED), 28031 Madrid, Spain; Institut de Neurociències, Universitat de
  • Cano A; Biomedical Research Networking Centre in Neurodegenerative Diseases (CIBERNED), 28031 Madrid, Spain; Department of Pharmacy, Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, Barcelona, Spain; Institute of Nanoscience and Nanotechnology
  • Busquets O; Departament de Farmacologia, Toxicologia i Química Terapèutica, Facultat de Farmàcia i Ciències del'Alimentació, Universitat de Barcelona, Barcelona, Spain; Biomedical Research Networking Centre in Neurodegenerative Diseases (CIBERNED), 28031 Madrid, Spain; Institut de Neurociències, Universitat de
  • Marcello E; Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Milano, Italy.
  • Pelucchi S; Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Milano, Italy; Department of Neurosciences, Psychology, Drug Research, and Child Health, University of Florence, Florence, Italy.
  • Di Luca M; Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Milano, Italy.
  • Endres K; Department of Psychiatry and Psychotherapy, University Medical Center Johannes Gutenberg-University Mainz, Mainz, Germany.
  • Olloquequi J; Instituto de Ciencias Biomédicas, Facultad de Ciencias de la Salud, Universidad Autónoma de Chile, Talca, Chile. Electronic address: jolloquequi@gmail.com.
  • Camins A; Departament de Farmacologia, Toxicologia i Química Terapèutica, Facultat de Farmàcia i Ciències del'Alimentació, Universitat de Barcelona, Barcelona, Spain; Biomedical Research Networking Centre in Neurodegenerative Diseases (CIBERNED), 28031 Madrid, Spain; Institut de Neurociències, Universitat de
  • Cominetti MR; Department of Gerontology, Federal University of São Carlos, São Carlos, Brazil.
Biomed Pharmacother ; 113: 108661, 2019 May.
Article em En | MEDLINE | ID: mdl-30836275
ABSTRACT
Alzheimer's disease (AD) represents a global burden in the economics of healthcare systems. Amyloid-ß (Aß) peptides are formed by amyloid-ß precursor protein (AßPP) cleavage, which can be processed by two pathways. The cleavage by the α-secretase A Disintegrin And Metalloprotease 10 (ADAM10) releases the soluble portion (sAßPPα) and prevents senile plaques. This pathway remains largely unknown and ignored, mainly regarding pharmacological approaches that may act via different signaling cascades and thus stimulate non-amyloidogenic cleavage through ADAM10. This review emphasizes the effects of natural compounds on ADAM10 modulation, which eventuates in a neuroprotective mechanism. Moreover, ADAM10 as an AD biomarker is revised. New treatments and preventive interventions targeting ADAM10 regulation for AD are necessary, considering the wide variety of ADAM10 substrates.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Extratos Vegetais / Catequina / Fármacos Neuroprotetores / Secretases da Proteína Precursora do Amiloide / Doença de Alzheimer / Proteína ADAM10 / Proteínas de Membrana Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Extratos Vegetais / Catequina / Fármacos Neuroprotetores / Secretases da Proteína Precursora do Amiloide / Doença de Alzheimer / Proteína ADAM10 / Proteínas de Membrana Idioma: En Ano de publicação: 2019 Tipo de documento: Article