Automatic image processing pipeline for tracking longitudinal vessel changes in magnetic resonance angiography.
J Magn Reson Imaging
; 50(4): 1063-1074, 2019 10.
Article
em En
| MEDLINE
| ID: mdl-30843642
ABSTRACT
BACKGROUND:
Cerebral vessel diameter changes objectively and automatically derived from longitudinal magnetic resonance angiography (MRA) facilitate quantification of vessel changes and further modeling.PURPOSE:
To characterize longitudinal changes in intracranial vessel diameter using time-of-flight (TOF) MRA. STUDY TYPE Retrospective longitudinal study. SUBJECT POPULATION IN all, 112 pediatric patients, aged 9.96 ± 4.59 years, with craniopharyngioma from 2006-2011 scanned annually. FIELD STRENGTH/SEQUENCE 1.5T and 3T TOF MRA. STATISTICAL TESTS Chi-square and Wilcoxon-Mann-Whitney tests. ASSESSMENT Manual measurements using interventional angiography was established as a reference standard for diameter measurements. Constant and linear quantile regression with absolute difference, percentage difference, and relative difference was used for outlier detection.RESULTS:
Major vessels surrounding the circle of Willis were successfully segmented except for posterior communicating arteries, mostly due to disease-related hypoplasia. Diameter measurements were calculated at 1-mm segments with a median computed vessel diameter of 1.25 mm. Diameter distortion due to registration was within 0.04 mm for 99% of vessel segments. Outlier detection using quantile regression detected less than 4.34% as being outliers. Outliers were more frequent in smaller vessels and proximity to bifurcations (P < 0.001). DATACONCLUSION:
Using the proposed method, objective changes in vessel diameter can be acquired noninvasively from routine longitudinal imaging. High-throughput analyses of imaging-derived vascular trees combined with clinical and treatment parameters will allow rigorous modeling of vessel diameter changes. LEVEL OF EVIDENCE 2 Technical Efficacy Stage 2 J. Magn. Reson. Imaging 2019;501063-1074.Palavras-chave
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MEDLINE
Assunto principal:
Neoplasias Hipofisárias
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Angiografia Cerebral
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Interpretação de Imagem Assistida por Computador
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Artérias Cerebrais
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Angiografia por Ressonância Magnética
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Craniofaringioma
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article