A case-control study of risk factors for intussusception among infants in eastern France after the introduction of the rotavirus vaccine.
Vaccine
; 37(32): 4587-4593, 2019 07 26.
Article
em En
| MEDLINE
| ID: mdl-30851968
OBJECTIVE: The objective of the present study was to investigate the risk factors for intussusception (IS) among infants, including vaccination against rotavirus. METHODS: Case-control study with systematic inclusion of all infants aged <1â¯year with suspected IS admitted to emergency departments in the eastern region of France between 1 April 2008 and 31 March 2012. All cases classed level 1 according to the Brighton classification were matched to 4 hospital controls. Two exposure windows were examined; exposure to the first dose of rotavirus vaccine in the 7 and in the 14â¯days prior to the occurrence of IS. RESULTS: A total of 115 cases were matched with 457 controls. The average vaccination coverage rate over the 4â¯years of study was 8.6%. Rotavirus vaccine was not found to be significantly associated with the occurrence of IS in the 7â¯days (odds ratio (OR) not calculated; pâ¯=â¯0.99) and in the 14â¯days after administration of one dose vaccine (OR 1.33, 95% confidence interval (CI) 0.14-12.82). Infant formula alone or combined with breastfeeding was associated with an excess risk of IS (OR 2.74, 95% CI 1.10-6.79). A history of gastroenteritis within 2â¯weeks prior to hospitalisation was also associated with an increased risk (OR 2.24, 95% CI 1.07-4.67). CONCLUSION: Our study indicates that infant formula alone or combined with breastfeeding is a risk factor for IS. A small, non-significant increase in the risk of IS was observed after rotavirus vaccination, although the low vaccine coverage rate likely precluded detection of a significant increase in risk.
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MEDLINE
Assunto principal:
Vacinação
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Vacinas contra Rotavirus
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Intussuscepção
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article