Perfluorinated substances, risk factors for multiple sclerosis and cellular immune activation.
J Neuroimmunol
; 330: 90-95, 2019 05 15.
Article
em En
| MEDLINE
| ID: mdl-30852181
ABSTRACT
Perfluorinated alkylated substances (PFASs) have immunomodulatory effects but the impact on multiple sclerosis (MS) and cellular immune functions is only sparsely described. In the present study, we found lower concentrations of the long chain PFAS perfluorooctane sulfonic acid (PFOS) in MS than in healthy controls (HC). In HC, we did not detect associations between PFOS concentrations and immune phenotypes. Analyzing the impact of known MS risk factors on cellular immune functions, we found that smoking and Epstein-Barr nuclear antigen 1 antibodies were associated with distinct circulating immune cell changes. In summary, current background PFAS exposure is not an important risk factor for MS.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Ácidos Alcanossulfônicos
/
Fluorocarbonos
/
Imunidade Celular
/
Esclerose Múltipla
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article