Cytoplasmic TDP-43 De-mixing Independent of Stress Granules Drives Inhibition of Nuclear Import, Loss of Nuclear TDP-43, and Cell Death.

Gasset-Rosa, Fatima; Lu, Shan; Yu, Haiyang; Chen, Cong; Melamed, Ze'ev; Guo, Lin; Shorter, James; Da Cruz, Sandrine; Cleveland, Don W

Gasset-Rosa, Fatima; Lu, Shan; Yu, Haiyang; Chen, Cong; Melamed, Ze'ev; Guo, Lin; Shorter, James; Da Cruz, Sandrine; Cleveland, Don W.

Afiliação

Gasset-Rosa F; Ludwig Institute for Cancer Research, University of California at San Diego, La Jolla, CA 92093, USA.
Lu S; Ludwig Institute for Cancer Research, University of California at San Diego, La Jolla, CA 92093, USA.
Yu H; Ludwig Institute for Cancer Research, University of California at San Diego, La Jolla, CA 92093, USA.
Chen C; Ludwig Institute for Cancer Research, University of California at San Diego, La Jolla, CA 92093, USA.
Melamed Z; Ludwig Institute for Cancer Research, University of California at San Diego, La Jolla, CA 92093, USA.
Guo L; Department of Biochemistry & Biophysics, University of Pennsylvania, Philadelphia, PA 19104-6059, USA.
Shorter J; Department of Biochemistry & Biophysics, University of Pennsylvania, Philadelphia, PA 19104-6059, USA.
Da Cruz S; Ludwig Institute for Cancer Research, University of California at San Diego, La Jolla, CA 92093, USA. Electronic address: sdacruz@ucsd.edu.
Cleveland DW; Ludwig Institute for Cancer Research, University of California at San Diego, La Jolla, CA 92093, USA; Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, CA 92093, USA. Electronic address: dcleveland@ucsd.edu.

Neuron ; 102(2): 339-357.e7, 2019 04 17.

Article em En | MEDLINE | ID: mdl-30853299

Assuntos

Morte Celular; Grânulos Citoplasmáticos/metabolismo; Proteínas de Ligação a DNA/metabolismo; Neurônios/metabolismo; Transição de Fase; Estresse Fisiológico; Transporte Ativo do Núcleo Celular; Esclerose Lateral Amiotrófica/metabolismo; Animais; Linhagem Celular Tumoral; Demência Frontotemporal/metabolismo; Proteínas Ativadoras de GTPase/metabolismo; Células HEK293; Humanos; Glicoproteínas de Membrana/metabolismo; Camundongos; Complexo de Proteínas Formadoras de Poros Nucleares/metabolismo; alfa Carioferinas/metabolismo; Proteína ran de Ligação ao GTP/metabolismo

Palavras-chave

ALS/FTD; RNA-binding proteins; TDP-43; TDP-43 de-mixing; iPSCs; liquid-liquid phase separation; low complexity domains; motor neurons; neurodegeneration; nucleocytoplasmic transport; stress granules

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Estresse Fisiológico / Morte Celular / Grânulos Citoplasmáticos / Transição de Fase / Proteínas de Ligação a DNA / Neurônios Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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