Tim-3 aggravates podocyte injury in diabetic nephropathy by promoting macrophage activation via the NF-&#954;B/TNF-&#945; pathway.

Yang, Huimin; Xie, Tingting; Li, Dengren; Du, Xianhong; Wang, Tixiao; Li, Chunyang; Song, Xiaojia; Xu, Leiqi; Yi, Fan; Liang, Xiaohong; Gao, Lifen; Yang, Xiangdong; Ma, Chunhong

Tim-3 aggravates podocyte injury in diabetic nephropathy by promoting macrophage activation via the NF-κB/TNF-α pathway.

Yang, Huimin; Xie, Tingting; Li, Dengren; Du, Xianhong; Wang, Tixiao; Li, Chunyang; Song, Xiaojia; Xu, Leiqi; Yi, Fan; Liang, Xiaohong; Gao, Lifen; Yang, Xiangdong; Ma, Chunhong.

Afiliação

Yang H; Key Laboratory for Experimental Teratology of Ministry of Education and Department of Immunology, Shandong University School of Basic Medical Science, Jinan, PR China; Department of Nephropathy, Qilu Hospital of Shandong University, Jinan, Shandong, PR China.
Xie T; Department of Nephropathy, Qilu Hospital of Shandong University, Jinan, Shandong, PR China.
Li D; Department of Nephropathy, Qilu Hospital of Shandong University, Jinan, Shandong, PR China.
Du X; Key Laboratory for Experimental Teratology of Ministry of Education and Department of Immunology, Shandong University School of Basic Medical Science, Jinan, PR China.
Wang T; Key Laboratory for Experimental Teratology of Ministry of Education and Department of Immunology, Shandong University School of Basic Medical Science, Jinan, PR China.
Li C; Key Laboratory for Experimental Teratology of Ministry of Education and Department of Immunology, Shandong University School of Basic Medical Science, Jinan, PR China.
Song X; Key Laboratory for Experimental Teratology of Ministry of Education and Department of Immunology, Shandong University School of Basic Medical Science, Jinan, PR China.
Xu L; Department of Gastroenterology, Qilu Hospital of Shandong University, Jinan, Shandong, PR China.
Yi F; Department of Pharmacology, Shandong University School of Basic Medical Science, Jinan, PR China.
Liang X; Key Laboratory for Experimental Teratology of Ministry of Education and Department of Immunology, Shandong University School of Basic Medical Science, Jinan, PR China.
Gao L; Key Laboratory for Experimental Teratology of Ministry of Education and Department of Immunology, Shandong University School of Basic Medical Science, Jinan, PR China.
Yang X; Department of Nephropathy, Qilu Hospital of Shandong University, Jinan, Shandong, PR China. Electronic address: yxd683@163.com.
Ma C; Key Laboratory for Experimental Teratology of Ministry of Education and Department of Immunology, Shandong University School of Basic Medical Science, Jinan, PR China. Electronic address: machunhong@sdu.edu.cn.

Mol Metab ; 23: 24-36, 2019 05.

Article em En | MEDLINE | ID: mdl-30862474

Assuntos

Nefropatias Diabéticas/metabolismo; Receptor Celular 2 do Vírus da Hepatite A/metabolismo; Ativação de Macrófagos; NF-kappa B/metabolismo; Podócitos/patologia; Fator de Necrose Tumoral alfa/metabolismo; Transferência Adotiva; Animais; Diabetes Mellitus Experimental/induzido quimicamente; Diabetes Mellitus Experimental/metabolismo; Nefropatias Diabéticas/induzido quimicamente; Nefropatias Diabéticas/patologia; Modelos Animais de Doenças; Técnicas de Inativação de Genes; Receptor Celular 2 do Vírus da Hepatite A/genética; Humanos; Macrófagos/metabolismo; Masculino; Proteínas de Membrana/metabolismo; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Knockout; Estreptozocina/farmacologia

Palavras-chave

Diabetic nephropathy; Macrophage; NF-κB; TNF-α; Tim-3

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: NF-kappa B / Fator de Necrose Tumoral alfa / Nefropatias Diabéticas / Podócitos / Receptor Celular 2 do Vírus da Hepatite A / Ativação de Macrófagos Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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