Kidney graft failure induced by BKPyV replication despite a strong reduction of the immunosuppressive therapy.
J Med Virol
; 91(9): 1698-1701, 2019 09.
Article
em En
| MEDLINE
| ID: mdl-30866070
ABSTRACT
BKPyV replication is a risk factor for the development of polyomavirus-associated nephropathy in kidney transplant recipients. Here, the case of a 42 years old Caucasian patient is described who developed a kidney allograft failure because of uncontrolled BKPyV replication 7 months after transplant despite a strong reduction of the immunosuppressive therapy. The genetic analysis of the noncoding control region did not show rearrangement but two point mutations at nucleotide positions 18 and 31 within P block. The mutation at position 31 involved the nuclear factor-1 site. Sequencing of the VP1 region revealed a subtype I/subgroup b-1.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Transplante de Rim
/
Vírus BK
/
Infecções por Polyomavirus
/
Sobrevivência de Enxerto
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article