Apolipoprotein E Gene Polymorphisms Are Risk Factors for Spontaneous Intracerebral Hemorrhage: A Systematic Review and Meta-analysis.
Curr Med Sci
; 39(1): 111-117, 2019 Feb.
Article
em En
| MEDLINE
| ID: mdl-30868499
ABSTRACT
Intracerebral hemorrhage (ICH) is a serious clinical disease with high morbidity, whose pathogenesis might be related to apolipoprotein E (APOE) gene polymorphisms. To comprehensively evaluate the risk factors for ICH occurrence, we performed a meta-analysis. We searched online databases to identify eligible studies based on the relationship between APOE genetic polymorphisms and ICH occurrence risk. Specific and pooled odds ratios (ORs) were calculated and by assessing small study bias, we drew the relationship between APOE polymorphisms and ICH risk. We included 15 eligible studies in our study containing a total of 1642 ICH samples and 5545 normal controls. The comparison of É4 and É3 APOE genotypes revealed that specific and pooled ORs showed a significantly increased odds ratio in ICH patients with the É4 genotype, indicating that É4 gene is a risk factor for ICH occurrence, and the heterogeneity is acceptable. Similarly, it was found that the É2 genotype also contributed to the incidence rate of ICH. However, after the subgroup analysis by ethnicity, this APOE genetic polymorphism acted as a harmful factor only in white populations, but did not show an effect in Asian populations. It was suggested that both ε2 and ε4 APOE alleles were risk factors for ICH in general. They were risk factors in white populations only, neither had a detectable effect in Asian populations after subgroup analysing by ethnicity.
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Base de dados:
MEDLINE
Assunto principal:
Apolipoproteínas E
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Polimorfismo Genético
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Hemorragia Cerebral
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População Branca
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article