An extensive pattern of atypical neural speech-sound discrimination in newborns at risk of dyslexia.
Clin Neurophysiol
; 130(5): 634-646, 2019 05.
Article
em En
| MEDLINE
| ID: mdl-30870799
ABSTRACT
OBJECTIVE:
Identifying early signs of developmental dyslexia, associated with deficient speech-sound processing, is paramount to establish early interventions. We aimed to find early speech-sound processing deficiencies in dyslexia, expecting diminished and atypically lateralized event-related potentials (ERP) and mismatch responses (MMR) in newborns at dyslexia risk.METHODS:
ERPs were recorded to a pseudoword and its variants (vowel-duration, vowel-identity, and syllable-frequency changes) from 88 newborns at high or no familial risk. The response significance was tested, and group, laterality, and frontality effects were assessed with repeated-measures ANOVA.RESULTS:
An early positive and right-lateralized ERP component was elicited by standard pseudowords in both groups, the response amplitude not differing between groups. Early negative MMRs were absent in the at-risk group, and MMRs to duration changes diminished compared to controls. MMRs to vowel changes had significant lateralityâ¯×â¯group interactions resulting from right-lateralized MMRs in controls.CONCLUSIONS:
The MMRs of high-risk infants were absent or diminished, and morphologically atypical, suggesting atypical neural speech-sound discrimination.SIGNIFICANCE:
This atypical neural basis for speech discrimination may contribute to impaired language development, potentially leading to future reading problems.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Córtex Auditivo
/
Percepção da Fala
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Fonética
/
Dislexia
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Potenciais Evocados Auditivos
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article