Ulipristal acetate decreases active TGF-ß3 and its canonical signaling in uterine leiomyoma via two novel mechanisms.

Lewis, Terrence D; Malik, Minnie; Britten, Joy; Parikh, Toral; Cox, Jeris; Catherino, William H

Ulipristal acetate decreases active TGF-ß3 and its canonical signaling in uterine leiomyoma via two novel mechanisms.

Lewis, Terrence D; Malik, Minnie; Britten, Joy; Parikh, Toral; Cox, Jeris; Catherino, William H.

Afiliação

Lewis TD; Department of Obstetrics and Gynecology, Uniformed Services University of the Health Sciences, Bethesda, Maryland; Program in Reproductive Endocrinology and Gynecology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland.
Malik M; Department of Obstetrics and Gynecology, Uniformed Services University of the Health Sciences, Bethesda, Maryland.
Britten J; Department of Obstetrics and Gynecology, Uniformed Services University of the Health Sciences, Bethesda, Maryland.
Parikh T; Department of Obstetrics and Gynecology, Uniformed Services University of the Health Sciences, Bethesda, Maryland; Program in Reproductive Endocrinology and Gynecology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland.
Cox J; Fort Belvoir Community Hospital, Fort Belvoir, Virginia.
Catherino WH; Department of Obstetrics and Gynecology, Uniformed Services University of the Health Sciences, Bethesda, Maryland; Program in Reproductive Endocrinology and Gynecology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland.

Fertil Steril ; 111(4): 806-815.e1, 2019 04.

Article em En | MEDLINE | ID: mdl-30871768

Assuntos

Leiomioma/genética; Norpregnadienos/farmacologia; Fator de Crescimento Transformador beta3/genética; Neoplasias Uterinas/genética; Adulto; Células Cultivadas; Regulação para Baixo/efeitos dos fármacos; Feminino; Regulação Neoplásica da Expressão Gênica/efeitos dos fármacos; Humanos; Leiomioma/metabolismo; Leiomioma/patologia; Cultura Primária de Células; Transdução de Sinais/efeitos dos fármacos; Transdução de Sinais/genética; Fator de Crescimento Transformador beta3/metabolismo; Neoplasias Uterinas/metabolismo; Neoplasias Uterinas/patologia

Palavras-chave

Leiomyoma; TGF-ß3; collagen; extracellular matrix; ulipristal acetate; veriscan

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Uterinas / Fator de Crescimento Transformador beta3 / Leiomioma / Norpregnadienos Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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