Convergent synthesis of the pentasaccharide repeating unit of the biofilms produced by Klebsiella pneumoniae.
Beilstein J Org Chem
; 15: 431-436, 2019.
Article
em En
| MEDLINE
| ID: mdl-30873227
ABSTRACT
A pentasaccharide repeating unit containing α-linked D-glucuronic acid, ß-linked D-mannose, corresponding to the repeating unit of biofilms produced by Klebsiella pneumoniae, has been synthesized using a stereoselective [2 + 3] convergent glycosylation strategy. The ß-D-mannosidic moiety has been synthesized using a D-mannose-derived thioglycoside by a two-step activation process. Late stage TEMPO-mediated oxidation of the pentasaccharide derivative using phase-transfer reaction conditions furnished the target compound in satisfactory yield.
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MEDLINE
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En
Ano de publicação:
2019
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Article