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The Effect of Topical Vitamin A and E on Ischemic Random Skin Flap Survival.
Hassanpour, Seyed Esmail; Rostami, Khalil; Azargashb, Eznollah; Saberi, Kourosh; Hamraz, Seyyed Hosein; Farajzadeh Vajari, Fatemeh; Molaei, Hojjat.
Afiliação
  • Hassanpour SE; Department of Plastic and Reconstructive Surgery, Medicine School, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Rostami K; Department of Plastic and Reconstructive Surgery, Medicine School, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Azargashb E; Department of Plastic and Reconstructive Surgery, Medicine School, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Saberi K; Department of Plastic and Reconstructive Surgery, Medicine School, Semnan University of Medical Sciences, Semnan, Iran.
  • Hamraz SH; Department of Plastic and Reconstructive Surgery, Medicine School, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Farajzadeh Vajari F; Gynecologist surgeon, Private Practice, Tehran, Iran.
  • Molaei H; Department of Plastic and Reconstructive Surgery, Imam Khomeini Hospital, Medicine School, Tehran University of Medical Sciences, Tehran, Iran.
World J Plast Surg ; 8(1): 58-61, 2019 Jan.
Article em En | MEDLINE | ID: mdl-30873363
BACKGROUND: Ischemia of skin flaps is an important complication in reconstructive surgery. This study evaluated the efficacy of topical vitamins A and E on improving flap survival. METHODS: Twenty-four white-albino male rats were randomly divided into two groups of treatment and control. Standard rectangular, distally based dorsal random pattern skin flap was elevated. Intra-peritoneal cephazoline was administered to prevent any unexpected infection. No pharmaceutical agent was administered for the control group, but pure vaseline ointment. In treatment group, vaseline plus vitamins A and E were administrated daily after surgery for 10 days. The rats were evaluated on the 10th day after surgery for viable and necrotic portions of the flaps. RESULTS: The mean values of necrosis in the flaps were 625±189.56 and 920.00±247.31 in the treatment and control groups, respectively. Vaseline plus vitamins increased flap survival significantly. CONCLUSION: Topical vitamins A and E may be effective pharmaceutical agents to increase viability of random skin flaps in rats. They can be added to vasoactive topical agents to reach better results.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2019 Tipo de documento: Article