Dual prophylaxis with teicoplanin and cefazolin in the prevention of prosthetic joint infection. / Profilaxis dual con teicoplanina añadida a cefazolina en la prevención de la infección de prótesis articular.
Enferm Infecc Microbiol Clin (Engl Ed)
; 37(9): 588-591, 2019 Nov.
Article
em En, Es
| MEDLINE
| ID: mdl-30876673
ABSTRACT
INTRODUCTION:
There is a growing increase in prosthetic joint infection (PJI) incidence due to cephalosporin-resistant bacteria, used in surgical prophylaxis. The replacement of these with glycopeptides has not been shown to improve the results, but they have been shown to improve with their combination.METHODS:
Comparative study of combination of teicoplanin and cefazolin before arthroplasty surgery against cefazolin alone from a previous control group.RESULTS:
During the control period, there were 16 PJIs from 585 surgeries, while in the intervention group there were 6 from 579 (incidence 2.7% vs. 1.03%, RR 0.4, P=.04). In control group, 11 of the infections were caused by Gram-positive bacteria versus 4 in the intervention group (1.8% vs. 0.7%, P=.08).CONCLUSIONS:
The addition of teicoplanin to cefazolin in the prophylaxis of arthroplasty surgery was associated with a reduction in the incidence of PJI, thanks to a decrease in infections caused by Gram-positive bacteria.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Infecção da Ferida Cirúrgica
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Infecções Bacterianas
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Artrite Infecciosa
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Cefazolina
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Infecções Relacionadas à Prótese
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Teicoplanina
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Antibioticoprofilaxia
Idioma:
En
/
Es
Ano de publicação:
2019
Tipo de documento:
Article