Microbiome diurnal rhythmicity and its impact on host physiology and disease risk.
EMBO Rep
; 20(4)2019 04.
Article
em En
| MEDLINE
| ID: mdl-30877136
ABSTRACT
Host-microbiome interactions constitute key determinants of host physiology, while their dysregulation is implicated in a wide range of human diseases. The microbiome undergoes diurnal variation in composition and function, and this in turn drives oscillations in host gene expression and functions. In this review, we discuss the newest developments in understanding circadian host-microbiome interplays, and how they may be relevant in health and disease contexts. We summarize the molecular mechanisms by which the microbiome influences host function in a diurnal manner, and inversely describe how the host orchestrates circadian rhythmicity of the microbiome. Furthermore, we highlight the future perspectives and challenges in studying this new and exciting facet of host-microbiome interactions. Finally, we illustrate how the elucidation of the microbiome chronobiology may pave the way for novel therapeutic approaches.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Ritmo Circadiano
/
Suscetibilidade a Doenças
/
Microbiota
/
Homeostase
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article