miR-500 promotes cell proliferation by directly targetting LRP1B in prostate cancer.
Biosci Rep
; 39(4)2019 04 30.
Article
em En
| MEDLINE
| ID: mdl-30877185
ABSTRACT
Accumulating evidence suggests that miRNAs play a crucial role in the development of prostate cancer (PC); however, the role of miR-500 in PC remains poorly understood. The data presented here reveal abnormal increases in miR-500 expression in PC tissues and cell lines. Suppression of miR-500 expression significantly inhibited the proliferation of PC-3 and LnCap cells and was negatively regulative with low-density lipoprotein receptor-related protein 1B (LRP1B). Increased cell cycle arrest at the G1 stage and decreased protein expression of cyclinD1 and CDK2 was observed in response to miR-500 knockdown in PC-3 and LnCap cells, in combination with LRP1B overexpression. LRP1B was identified as a target of miR-500 and was significantly decreased in PC tissues. Taken together, these findings demonstrate that miR-500 plays an important role in the proliferation of PC cells via the inhibition of LRP1B expression.
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Próstata
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Receptores de LDL
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Regulação Neoplásica da Expressão Gênica
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MicroRNAs
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Proliferação de Células
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article