Heliaquanoids A-E, Five Sesquiterpenoid Dimers from Inula helianthus-aquatica.
J Org Chem
; 84(7): 4473-4477, 2019 04 05.
Article
em En
| MEDLINE
| ID: mdl-30882223
ABSTRACT
Heliaquanoid A (1), the first exo-2,4-linked Diels-Alder adduct between a pseudoguaianolide dienophile and a guaianolide diene, and heliaquanoids B-E (2-5), four new 2,4-linked Diels-Alder adducts between a xanthanolide dienophile and a guaianolide diene, were isolated from stems and leaves of Inula helianthus-aquatica. Their structures were determined by NMR spectroscopy, a modified Mosher's method, electronic circular dichroism, and X-ray diffraction analysis. Compounds 2 and 3 exhibited moderate cytotoxic activities against HL-60 cells with IC50 values of 7.5 and 4.9 µM, respectively.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Sesquiterpenos
/
Inula
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article