Serotonin receptor HTR6-mediated mTORC1 signaling regulates dietary restriction-induced memory enhancement.
PLoS Biol
; 17(3): e2007097, 2019 03.
Article
em En
| MEDLINE
| ID: mdl-30883547
ABSTRACT
Dietary restriction (DR; sometimes called calorie restriction) has profound beneficial effects on physiological, psychological, and behavioral outcomes in animals and in humans. We have explored the molecular mechanism of DR-induced memory enhancement and demonstrate that dietary tryptophan-a precursor amino acid for serotonin biosynthesis in the brain-and serotonin receptor 5-hydroxytryptamine receptor 6 (HTR6) are crucial in mediating this process. We show that HTR6 inactivation diminishes DR-induced neurological alterations, including reduced dendritic complexity, increased spine density, and enhanced long-term potentiation (LTP) in hippocampal neurons. Moreover, we find that HTR6-mediated mechanistic target of rapamycin complex 1 (mTORC1) signaling is involved in DR-induced memory improvement. Our results suggest that the HTR6-mediated mTORC1 pathway may function as a nutrient sensor in hippocampal neurons to couple memory performance to dietary intake.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Receptores de Serotonina
/
Alvo Mecanístico do Complexo 1 de Rapamicina
/
Memória
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article