Contact sensitization to hair colours in acquired dermal macular hyperpigmentation: results from a patch and photo-patch test study of 108 patients.
J Eur Acad Dermatol Venereol
; 33(7): 1349-1357, 2019 Jul.
Article
em En
| MEDLINE
| ID: mdl-30883932
ABSTRACT
BACKGROUND:
Acquired dermal macular hyperpigmentation (ADMH) is an umbrella term including lichen planus pigmentosus, erythema dyschromicum perstans and pigmented contact/cosmetic dermatitis.OBJECTIVE:
To establish contact sensitization to hair colours as an aetiological factor for ADMH.METHODS:
Detailed clinical examination, skin biopsies, and patch and photo-patch testing with Indian standard series and patient's own cosmetic products were performed.RESULTS:
Thirty-nine (36.1%) patients were found to demonstrate a positive patch/photo-patch test with 35/39 reacting to their own products (all were hair colours) and 16/39 reacting to antigens from commercial series (commonly paraphenylenediamine). Fourteen patients developed delayed hyperpigmentation on positive patch-test sites at 1 month. Higher mean age, symptomatic pigmentation (pruritus, burning and photosensitivity), hair margins involvement (outer surface, helix and lobule of ear; temples and preauricular area), ill-defined lesions, epidermal atrophy and epidermal melanization extending >3 layers were significantly common in patch-test-positive patients. Well-defined lesions, perioral involvement and associated lichen planus were clinical pointers towards patch-test negativity.CONCLUSION:
Index study exemplifies that patch-test results have distinct clinical and histopathological correlates in ADMH. Hair dye contact sensitization appears to be an important aetiological factor in about one-third patients presenting with ADMH.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Hiperpigmentação
/
Dermatite Perioral
/
Dermatite de Contato
/
Tinturas para Cabelo
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article