Association study of Apolipoprotein A5 gene (APOA5 gene) variant with the metabolic syndrome in local Pakistani population.
J Pak Med Assoc
; 69(3): 301-305, 2019 Mar.
Article
em En
| MEDLINE
| ID: mdl-30890818
ABSTRACT
OBJECTIVE:
To explore the association of rs662799 variants of Apolipoprotein A5 gene with metabolic syndrome in Pakistani population.METHODS:
The case-control study was conducted at Pakistan Institute of Medical Sciences, Islamabad, Pakistan from 2014 to2016, and comprised subjects enrolled from the out-patient clinics. Groups were formed on the basis of preliminary screening for risk factors like obesity, insulin resistance, hypertension, dyslipidemia and fasting blood glucose levels. Met S was diagnosed based on the international diabetes federation criteria. Blood samples were collected for biochemical testing and deoxyribonucleic acid extraction. Genotyping of rs662799 was performed a the Genome Research Centre of the University of Hong Kong using Sequenom Mass ARRAY, iPLEX Gold technology. Data was analysed using SPSS 16and Plink software.RESULTS:
There were 712 subjects in two groups of 356(50%) each. The overall mean age was 41.59}7.18 years. There was a significant association of risk allele C of rs662799 with metabolic syndrome (p=0.002). The risk showed strong association with dyslipidaemia (p=0.03) and obesity (p=0.01) which are risk phenotypes of metabolic syndrome in age- and gender-adjusted model.CONCLUSIONS:
The association of risk allele C of genetic variant rs662799 of Apolipoprotein A5 gene with dyslipidaemia and obesity may lead to the development of metabolic syndrome in the Pakistan adult population.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Síndrome Metabólica
/
Dislipidemias
/
Apolipoproteína A-V
/
Obesidade
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article