Difference in Treatment Effect Between Intravitreal Aflibercept Injection and Laser by Baseline Factors in Diabetic Macular Edema.
Ophthalmic Surg Lasers Imaging Retina
; 50(3): 167-173, 2019 03 01.
Article
em En
| MEDLINE
| ID: mdl-30893450
ABSTRACT
BACKGROUND AND OBJECTIVE:
To evaluate the effect of baseline factors on differences in vision gains with intravitreal aflibercept injection (IAI) versus laser control in patients with diabetic macular edema (DME). PATIENTS ANDMETHODS:
This was an integrated post-hoc subanalysis of two phase 3 trials (VISTA, VIVID) in patients with DME. Least square (LS) mean differences of patients treated with IAI compared to laser control in best-corrected visual acuity (BCVA) change from baseline at week 100 were evaluated for association with baseline demographics and baseline systemic disease characteristics.RESULTS:
At week 100, LS mean differences in BCVA change from baseline with IAI compared to laser control were not significant for association with baseline age, gender, and race or status of glycosylated hemoglobin, body mass index, renal impairment, hypertension, cerebrovascular disease, and ischemic heart disease.CONCLUSION:
Vision gains with IAI were significantly greater than laser control and were not influenced by demographics and systemic disease control at baseline. [Ophthalmic Surg Lasers Imaging Retina. 2019;50167-173.].
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Proteínas Recombinantes de Fusão
/
Edema Macular
/
Fotocoagulação a Laser
/
Inibidores da Angiogênese
/
Receptores de Fatores de Crescimento do Endotélio Vascular
/
Retinopatia Diabética
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article