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Structural determinants of inhibition of Porphyromonas gingivalis gingipain K by KYT-36, a potent, selective, and bioavailable peptidase inhibitor.
Guevara, Tibisay; Rodríguez-Banqueri, Arturo; Lasica, Anna M; Ksiazek, Miroslaw; Potempa, Barbara A; Potempa, Jan; Gomis-Rüth, F Xavier.
Afiliação
  • Guevara T; Proteolysis Lab, Structural Biology Unit, "María de Maeztu" Unit of Excellence, Molecular Biology Institute of Barcelona (CSIC), Barcelona Science Park, Helix Building, c/Baldiri Reixac, 15-21, 08028, Barcelona, Catalonia, Spain.
  • Rodríguez-Banqueri A; Proteolysis Lab, Structural Biology Unit, "María de Maeztu" Unit of Excellence, Molecular Biology Institute of Barcelona (CSIC), Barcelona Science Park, Helix Building, c/Baldiri Reixac, 15-21, 08028, Barcelona, Catalonia, Spain.
  • Lasica AM; Department of Bacterial Genetics, Faculty of Biology, University of Warsaw, ul. Miecznikowa 1, 02-096, Warszawa, Poland.
  • Ksiazek M; Department of Oral Immunology and Infectious Diseases, University of Louisville School of Dentistry, 501 South Preston Street, Louisville, KY, 40202, USA.
  • Potempa BA; Department of Oral Immunology and Infectious Diseases, University of Louisville School of Dentistry, 501 South Preston Street, Louisville, KY, 40202, USA.
  • Potempa J; Department of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, ul. Gronostajowa 7, 30-387, Kraków, Poland.
  • Gomis-Rüth FX; Department of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, ul. Gronostajowa 7, 30-387, Kraków, Poland.
Sci Rep ; 9(1): 4935, 2019 03 20.
Article em En | MEDLINE | ID: mdl-30894633
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Periodontite / Inibidores de Proteases / Benzilaminas / Carbamatos / Infecções por Bacteroidaceae / Porphyromonas gingivalis / Cisteína Endopeptidases Gingipaínas / Hidrazinas Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Periodontite / Inibidores de Proteases / Benzilaminas / Carbamatos / Infecções por Bacteroidaceae / Porphyromonas gingivalis / Cisteína Endopeptidases Gingipaínas / Hidrazinas Idioma: En Ano de publicação: 2019 Tipo de documento: Article