Chromone-Derived Polyketides from the Deep-Sea Fungus Diaporthe phaseolorum FS431.
Mar Drugs
; 17(3)2019 Mar 20.
Article
em En
| MEDLINE
| ID: mdl-30897716
ABSTRACT
Five new chromone-derived polyketides phaseolorins A-F (1â»5), together with nine known compounds, were isolated from the deep-sea derived fungus Diaporthe phaseolorum FS431. The structures of new compounds were determined by analysis of their NMR and high-resolution electrospray ionization mass spectroscopy (HRESIMS) spectroscopic data. The absolute configurations were confirmed by chemical transformations, extensively experimental electron capture detection (ECD) calculations, or X-ray crystallography. Among them, compound 2 represented the first example for a new family of chromone derivative possessing an unprecedented recombined five-member γ-lactone ring. Moreover, the new compounds (1â»5) were evaluated for in vitro cytotoxic activities against a panel of human cancer cell lines.
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Base de dados:
MEDLINE
Assunto principal:
Organismos Aquáticos
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Policetídeos
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Fungos
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article