Human Antibody Bispecifics through Phage Display Selection.
Biochemistry
; 58(13): 1701-1704, 2019 04 02.
Article
em En
| MEDLINE
| ID: mdl-30900875
ABSTRACT
We developed a repertoire approach to generate human antibody bispecifics. Using phage display selection of antibody heavy chains in the presence of a competitor light chain and providing a cognate light chain with an affinity handle, we identified mutations that prevent heavy/light chain mispairing. The strategy allows for the selection of human antibody chains that autonomously assemble into bispecifics.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Anticorpos Biespecíficos
/
Biblioteca de Peptídeos
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article