Recombinant Viral Vectors as Neuroscience Tools.
Curr Protoc Neurosci
; 87(1): e67, 2019 04.
Article
em En
| MEDLINE
| ID: mdl-30901512
ABSTRACT
Recombinant viruses are highly efficient vehicles for in vivo gene delivery. Viral vectors expand the neurobiology toolbox to include direct and rapid anterograde, retrograde, and trans-synaptic delivery of tracers, sensors, and actuators to the mammalian brain. Each viral type offers unique advantages and limitations. To establish strategies for selecting a suitable viral type, this article aims to provide readers with an overview of viral recombinant technology, viral structure, tropism, and differences between serotypes and pseudotypes for three of the most commonly used vectors in neurobiology research adeno-associated viruses, retro/lentiviruses, and glycoprotein-deleted rabies viruses. © 2019 by John Wiley & Sons, Inc.
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Base de dados:
MEDLINE
Assunto principal:
Neurociências
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Terapia Genética
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Dependovirus
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Vetores Genéticos
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article