Enzymatic interconversion of the oxysterols 7ß,25-dihydroxycholesterol and 7-keto,25-hydroxycholesterol by 11ß-hydroxysteroid dehydrogenase type 1 and 2.

Beck, Katharina R; Kanagaratnam, Sharavan; Kratschmar, Denise V; Birk, Julia; Yamaguchi, Hideaki; Sailer, Andreas W; Seuwen, Klaus; Odermatt, Alex

Beck, Katharina R; Kanagaratnam, Sharavan; Kratschmar, Denise V; Birk, Julia; Yamaguchi, Hideaki; Sailer, Andreas W; Seuwen, Klaus; Odermatt, Alex.

Afiliação

Beck KR; Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50, 4056 Basel, Switzerland.
Kanagaratnam S; Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50, 4056 Basel, Switzerland.
Kratschmar DV; Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50, 4056 Basel, Switzerland.
Birk J; Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50, 4056 Basel, Switzerland.
Yamaguchi H; Department of Applied Biological Chemistry, Meijo University, Nagoya 468-8502, Japan.
Sailer AW; Disease Area X, Novartis Institutes for BioMedical Research, Basel, Switzerland.
Seuwen K; Disease Area X, Novartis Institutes for BioMedical Research, Basel, Switzerland.
Odermatt A; Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50, 4056 Basel, Switzerland. Electronic address: Alex.Odermatt@unibas.ch.

J Steroid Biochem Mol Biol ; 190: 19-28, 2019 06.

Article em En | MEDLINE | ID: mdl-30902677

Assuntos

11-beta-Hidroxiesteroide Desidrogenase Tipo 1/metabolismo; 11-beta-Hidroxiesteroide Desidrogenase Tipo 2/metabolismo; Hidroxicolesteróis/metabolismo; Cetocolesteróis/metabolismo; Animais; Células HEK293; Humanos; Hidroxilação; Camundongos; Camundongos Endogâmicos C57BL; Simulação de Acoplamento Molecular; Oxirredução; Células RAW 264.7

Palavras-chave

11beta-hydroxysteroid dehydrogenase; 7-ketocholesterol; Cholesterol 25-hydroxylase; Epstein-Barr virus-induced gene 2; Metabolism; Oxysterol

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: 11-beta-Hidroxiesteroide Desidrogenase Tipo 1 / 11-beta-Hidroxiesteroide Desidrogenase Tipo 2 / Hidroxicolesteróis / Cetocolesteróis Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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