CASP9 c.-1339A>G and CASP3 c.-1191A>G polymorphisms alter susceptibility and clinical aspects of head and neck squamous cell carcinoma.
Head Neck
; 41(8): 2665-2670, 2019 08.
Article
em En
| MEDLINE
| ID: mdl-30903678
ABSTRACT
BACKGROUND:
Single nucleotide polymorphisms (SNPs) in genes that act in intrinsic apoptosis pathway may modulate cancer susceptibility. This study investigated the roles of CASP9 c.-1339A>G (rs4645978) and CASP3 c.-1191A>G (rs12108497) SNPs on risk and behavior of head and neck (HN) squamous cell carcinoma (SCC).METHODS:
DNA of 350 patients with HNSCC and 350 controls was analyzed by polymerase chain reaction method for genotyping.RESULTS:
CASP3 c.-1191AG or GG genotype was more common in patients with HNSCC and oral cavity or oropharynx SCC than in controls; carriers of this genotype were under 2.15 and 2.81-fold increased risks of the respective tumors. CASP9 c.-1339AG or GG plus CASP3 c.-1191AG or GG genotypes were associated with oral cavity or oropharynx SCC early onset.CONCLUSION:
These findings present, for the first time, preliminary evidence that inherited abnormalities related to CASP9 c.-1339A>G and CASP3 c.-1191A>G SNPs are determinants of HNSCC risk and clinical aspects.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias Bucais
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Neoplasias Faríngeas
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Neoplasias Laríngeas
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Predisposição Genética para Doença
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Polimorfismo de Nucleotídeo Único
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Caspase 3
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Caspase 9
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Carcinoma de Células Escamosas de Cabeça e Pescoço
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article