Combination of sepsis biomarkers may indicate an invasive fungal infection in haematological patients.
Biomarkers
; 24(4): 401-406, 2019 Jun.
Article
em En
| MEDLINE
| ID: mdl-30907674
ABSTRACT
Background:
Invasive fungal infections are a major threat to a large cohort of immunocompromised patients, including patients with chemotherapy-associated neutropenia. Early differential diagnosis with bacterial infections is often complicated, which leads to a delay in empirical antifungal therapy and increases risk for adverse outcome. Accessibility and performance of specific fungal antigen and PCR-tests are still limited, while sepsis biomarkers are more broadly used in most settings currently.Methods:
Haematological patients hospitalized to receive chemotherapy with proven or probable invasive fungal infection or microbiologically proven bacterial bloodstream infection were included in the study. C-reactive protein was assessed daily during the profound neutropenia period, while procalcitonin or presepsin were measured during the first 48 hours after the onset of febrile episode.Results:
There were totally 64 patients included in the study, 53 with bacterial bloodstream infections and 11 with invasive fungal infections. Combination of CRP >120 with PCT <1.25 or presepsin <170 was shown to be a possible combined biomarker for invasive fungal infections in immunocompromised patients, with areas under the ROC-curves 0.962 (95% CI 0.868 to 0.995) for PCT-based combination and 0.907 (95% CI 0.692 to 0.990) for presepsin-based combination.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Fragmentos de Peptídeos
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Infecções Bacterianas
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Infecções Oportunistas
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Proteína C-Reativa
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Sepse
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Receptores de Lipopolissacarídeos
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Infecções Fúngicas Invasivas
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Pró-Calcitonina
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article