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SLC1A5 glutamine transporter is a target of MYC and mediates reduced mTORC1 signaling and increased fatty acid oxidation in long-lived Myc hypomorphic mice.
Zhao, Xiaoai; Petrashen, Anna P; Sanders, Jennifer A; Peterson, Abigail L; Sedivy, John M.
Afiliação
  • Zhao X; Department of Molecular Biology, Cell Biology and Biochemistry, and Center on the Biology of Aging, Brown University, Providence, Rhode Island.
  • Petrashen AP; Department of Molecular Biology, Cell Biology and Biochemistry, and Center on the Biology of Aging, Brown University, Providence, Rhode Island.
  • Sanders JA; Department of Pediatrics, Rhode Island Hospital and Brown University, Providence, Rhode Island.
  • Peterson AL; Department of Molecular Biology, Cell Biology and Biochemistry, and Center on the Biology of Aging, Brown University, Providence, Rhode Island.
  • Sedivy JM; Department of Molecular Biology, Cell Biology and Biochemistry, and Center on the Biology of Aging, Brown University, Providence, Rhode Island.
Aging Cell ; 18(3): e12947, 2019 06.
Article em En | MEDLINE | ID: mdl-30909319
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Antígenos de Histocompatibilidade Menor / Proteínas Proto-Oncogênicas c-myc / Sistema ASC de Transporte de Aminoácidos / Serina-Treonina Quinases TOR / Alvo Mecanístico do Complexo 1 de Rapamicina / Glutamina / Longevidade Idioma: En Ano de publicação: 2019 Tipo de documento: Article
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Antígenos de Histocompatibilidade Menor / Proteínas Proto-Oncogênicas c-myc / Sistema ASC de Transporte de Aminoácidos / Serina-Treonina Quinases TOR / Alvo Mecanístico do Complexo 1 de Rapamicina / Glutamina / Longevidade Idioma: En Ano de publicação: 2019 Tipo de documento: Article