Lessons learned from a lncRNA odyssey for two genes with vascular functions, DLL4 and TIE1.
Vascul Pharmacol
; 114: 103-109, 2019 03.
Article
em En
| MEDLINE
| ID: mdl-30910126
ABSTRACT
Pervasive transcription is a feature of the human genome that requires better understanding. Over the last decade or so, RNA species longer than 200 nucleotides-dubbed long non-coding RNA (lncRNAs)-had been found in sense or anti-sense orientation within or outside of genes that encode proteins. Importantly, lncRNA-mediated gene regulation and the elements that control lncRNA expression are a source of fascination among molecular biologists. In vascular biology, a dozen or so lncRNAs had been identified, and progress occurs each day. In this review, we highlighted our laboratories' contribution to the lncRNA field by discussing lessons learned from two lncRNAs in the tyrosine kinase containing immunoglobulin and epidermal growth factor homology1 (Tie1) and delta-like 4 (Dll4) loci. These genes are responsible for basic vascular patterning and pathophysiological remodeling in angiogenesis.
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MEDLINE
Assunto principal:
Neovascularização Fisiológica
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Peptídeos e Proteínas de Sinalização Intercelular
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Receptor de TIE-1
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RNA Longo não Codificante
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Remodelação Vascular
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article