Skin Wounding-Induced Monocyte Expansion in Mice Is Not Abrogated by IL-1 Receptor 1 Deficiency.
J Immunol
; 202(9): 2720-2727, 2019 05 01.
Article
em En
| MEDLINE
| ID: mdl-30910860
ABSTRACT
The aim of this study was to determine whether skin wounding induces monocyte (Mo) expansion in bone marrow and whether IL-1R1 signaling regulates this process. Our data show that skin wounding increases myeloid lineage-committed multipotent progenitors (MPP3 subset) and Mo in bone marrow, but this expansion is not impaired in Il1r1-/- mice. We also demonstrate that M-CSF-induced differentiation of myeloid progenitors into Mo is not impaired by the loss of IL-1R1 ex vivo, indicating that IL-R1 deficiency does not abrogate myeloid progenitor differentiation potential. In addition, we observed modestly delayed wound closure in Il1r1-/- mice associated with higher frequency of Ly6Clo Mo in the circulation at baseline and in wounds early after injury. Thus, in contrast to other models of inflammation that involve IL-1R1-dependent monopoiesis, our results demonstrate that skin wounding induces Mo progenitor and Mo expansion independently of IL-1R1 signaling.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Pele
/
Cicatrização
/
Ferimentos e Lesões
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Medula Óssea
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Monócitos
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Receptores Tipo I de Interleucina-1
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article