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Soluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer's disease model.
Zhong, Li; Xu, Ying; Zhuo, Rengong; Wang, Tingting; Wang, Kai; Huang, Ruizhi; Wang, Daxin; Gao, Yue; Zhu, Yifei; Sheng, Xuan; Chen, Kai; Wang, Na; Zhu, Lin; Can, Dan; Marten, Yuka; Shinohara, Mitsuru; Liu, Chia-Chen; Du, Dan; Sun, Hao; Wen, Lei; Xu, Huaxi; Bu, Guojun; Chen, Xiao-Fen.
Afiliação
  • Zhong L; Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, School of Medicine, Xiamen University, Xiamen, 361102, China.
  • Xu Y; Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, School of Medicine, Xiamen University, Xiamen, 361102, China.
  • Zhuo R; Department of Traditional Chinese Medicine, School of Medicine, Xiamen University, Xiamen, 361102, China.
  • Wang T; Xiamen Key Laboratory of Chiral Drugs, School of Medicine, Xiamen University, Xiamen, 361102, China.
  • Wang K; Shenzhen Research Institute of Xiamen University, Shenzhen, 518063, China.
  • Huang R; Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, School of Medicine, Xiamen University, Xiamen, 361102, China.
  • Wang D; Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, School of Medicine, Xiamen University, Xiamen, 361102, China.
  • Gao Y; Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, School of Medicine, Xiamen University, Xiamen, 361102, China.
  • Zhu Y; Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, School of Medicine, Xiamen University, Xiamen, 361102, China.
  • Sheng X; Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, School of Medicine, Xiamen University, Xiamen, 361102, China.
  • Chen K; Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, School of Medicine, Xiamen University, Xiamen, 361102, China.
  • Wang N; Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, School of Medicine, Xiamen University, Xiamen, 361102, China.
  • Zhu L; Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, School of Medicine, Xiamen University, Xiamen, 361102, China.
  • Can D; Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, School of Medicine, Xiamen University, Xiamen, 361102, China.
  • Marten Y; Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, School of Medicine, Xiamen University, Xiamen, 361102, China.
  • Shinohara M; Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, School of Medicine, Xiamen University, Xiamen, 361102, China.
  • Liu CC; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, 32224, USA.
  • Du D; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, 32224, USA.
  • Sun H; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, 32224, USA.
  • Wen L; School of Medicine, Xiamen University, Xiamen, 361102, China.
  • Xu H; Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, School of Medicine, Xiamen University, Xiamen, 361102, China.
  • Bu G; Department of Traditional Chinese Medicine, School of Medicine, Xiamen University, Xiamen, 361102, China.
  • Chen XF; Neuroscience Initiative, Sanford-Burnham-Prebys Medical Discovery Institute, La Jolla, CA, 92037, USA.
Nat Commun ; 10(1): 1365, 2019 03 25.
Article em En | MEDLINE | ID: mdl-30911003
Assuntos
Doença de Alzheimer/terapia; Potenciação de Longa Duração/efeitos dos fármacos; Glicoproteínas de Membrana/genética; Microglia/efeitos dos fármacos; Placa Amiloide/terapia; Receptores Imunológicos/genética; Memória Espacial/efeitos dos fármacos; Doença de Alzheimer/genética; Doença de Alzheimer/metabolismo; Doença de Alzheimer/patologia; Peptídeos beta-Amiloides/química; Peptídeos beta-Amiloides/metabolismo; Animais; Animais Recém-Nascidos; Encéfalo/efeitos dos fármacos; Encéfalo/metabolismo; Encéfalo/patologia; Movimento Celular/efeitos dos fármacos; Proliferação de Células/efeitos dos fármacos; Dependovirus/genética; Dependovirus/metabolismo; Modelos Animais de Doenças; Feminino; Expressão Gênica; Vetores Genéticos/química; Vetores Genéticos/metabolismo; Proteínas de Fluorescência Verde/genética; Proteínas de Fluorescência Verde/metabolismo; Humanos; Injeções Intraventriculares; Potenciação de Longa Duração/fisiologia; Masculino; Glicoproteínas de Membrana/administração & dosagem; Glicoproteínas de Membrana/metabolismo; Camundongos; Microglia/metabolismo; Microglia/patologia; Neurônios/efeitos dos fármacos; Neurônios/metabolismo; Neurônios/patologia; Fragmentos de Peptídeos/química; Fragmentos de Peptídeos/metabolismo; Fenótipo; Placa Amiloide/genética; Placa Amiloide/metabolismo; Placa Amiloide/patologia; Cultura Primária de Células; Proteólise; Receptores Imunológicos/administração & dosagem; Receptores Imunológicos/metabolismo; Proteínas Recombinantes de Fusão/administração & dosagem; Proteínas Recombinantes de Fusão/genética; Proteínas Recombinantes de Fusão/metabolismo; Memória Espacial/fisiologia; Técnicas Estereotáxicas
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Glicoproteínas de Membrana / Receptores Imunológicos / Microglia / Potenciação de Longa Duração / Placa Amiloide / Doença de Alzheimer / Memória Espacial Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Glicoproteínas de Membrana / Receptores Imunológicos / Microglia / Potenciação de Longa Duração / Placa Amiloide / Doença de Alzheimer / Memória Espacial Idioma: En Ano de publicação: 2019 Tipo de documento: Article