What is the optimal time for measuring glucose concentration to detect steroid-induced hyperglycemia in patients with rheumatic diseases?
Clin Biochem
; 67: 33-39, 2019 May.
Article
em En
| MEDLINE
| ID: mdl-30914158
ABSTRACT
OBJECTIVE:
Corticosteroids may cause hyperglycemia and diabetes mellitus (DM). Development of DM during long-term steroid use has been well studied; however, data regarding the short-term effects of steroid therapy are scarce. In this study, we aimed to detect the actual time of short-term steroid-induced hyperglycemia in patients without previous impaired glucose metabolism, and the ideal time (which day and in relation to meals) of glucose measurement.METHODS:
The 7-point blood glucose (BG) measurements of patients who were commenced moderate to high-dose steroids (≥15â¯mg/day prednisolone or its equivalent) due to rheumatological diseases during the first 5â¯days of steroid therapy were recorded. Fasting BGâ¯≥â¯7â¯mmol/L (126â¯mg/dL) or random BGâ¯≥â¯11.1â¯mmol/L (200â¯mg/dL) were considered as overt DM in accordance with the 2016 American Diabetes Association guideline, and post-meal BG ≥10â¯mmol/L (180â¯mg/dL) was considered as steroid-induced hyperglycemia.RESULTS:
Fifteen males (mean age 44⯱â¯16â¯years) and 35 females (mean age 41⯱â¯12â¯years) were recruited to the study. One thousand seven hundred fifty fasting, pre-meal, and 2-hours post-meal BG concentrations were analyzed. Twenty-one (42%) patients developed steroid-induced DM and 39 (78%) developed steroid-induced hyperglycemia. The highest glucose concentrations were detected on the 3rd day of steroid therapy and 2-h after meals (pâ¯<â¯.0001).CONCLUSION:
Intermediate to high-dose steroid therapy causes hyperglycemia after lunch and dinner on the 3rd day of treatment. This time period should be taken into consideration in the detection and treatment of steroid-induced hyperglycemia.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Glicemia
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Prednisolona
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Doenças Reumáticas
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Corticosteroides
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Hiperglicemia
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article