Hyperglycemia-induced oxidative brain injury: Therapeutic effects of Cola nitida infusion against redox imbalance, cerebellar neuronal insults, and upregulated Nrf2 expression in type 2 diabetic rats.

Erukainure, Ochuko L; Ijomone, Omamuyovwi M; Oyebode, Olajumoke A; Chukwuma, Chika I; Aschner, Michael; Islam, Md Shahidul

Erukainure, Ochuko L; Ijomone, Omamuyovwi M; Oyebode, Olajumoke A; Chukwuma, Chika I; Aschner, Michael; Islam, Md Shahidul.

Afiliação

Erukainure OL; Department of Biochemistry, School of Life Sciences, University of KwaZulu-Natal, (Westville Campus), Durban, 4000, South Africa; Nutrition and Toxicology Division, Federal Institute of Industrial Research, Lagos, Nigeria.
Ijomone OM; Department of Molecular Pharmacology, Albert Einstein College of Medicine, New York, USA; Department of Human Anatomy, Federal University of Technology, Akure, Nigeria.
Oyebode OA; Department of Biochemistry, School of Life Sciences, University of KwaZulu-Natal, (Westville Campus), Durban, 4000, South Africa.
Chukwuma CI; Department of Biochemistry, School of Life Sciences, University of KwaZulu-Natal, (Westville Campus), Durban, 4000, South Africa; Department of Health and Environmental Sciences, Central University of Technology, Bloemfontein, South Africa.
Aschner M; Department of Molecular Pharmacology, Albert Einstein College of Medicine, New York, USA.
Islam MS; Department of Biochemistry, School of Life Sciences, University of KwaZulu-Natal, (Westville Campus), Durban, 4000, South Africa. Electronic address: islamd@ukzn.ac.za.

Food Chem Toxicol ; 127: 206-217, 2019 May.

Article em En | MEDLINE | ID: mdl-30914353

Assuntos

Lesões Encefálicas/tratamento farmacológico; Cerebelo/efeitos dos fármacos; Cola/química; Diabetes Mellitus Experimental/metabolismo; Diabetes Mellitus Tipo 2/metabolismo; Hiperglicemia/complicações; Fator 2 Relacionado a NF-E2/metabolismo; Neurônios/patologia; Estresse Oxidativo; Extratos Vegetais/uso terapêutico; Regulação para Cima; Animais; Antioxidantes/farmacologia; Lesões Encefálicas/etiologia; Cerebelo/metabolismo; Cerebelo/patologia; Masculino; Oxirredução; Extratos Vegetais/farmacologia; Ratos Sprague-Dawley

Palavras-chave

Cola nitida; Neurodegeneration; Nrf2; SEM-EDX; Type 2 diabetes

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Lesões Encefálicas / Extratos Vegetais / Regulação para Cima / Cerebelo / Estresse Oxidativo / Cola / Diabetes Mellitus Experimental / Diabetes Mellitus Tipo 2 / Fator 2 Relacionado a NF-E2 / Hiperglicemia Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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