para-Selective C-H Olefination of Aniline Derivatives via Pd/S,O-Ligand Catalysis.
J Am Chem Soc
; 141(16): 6719-6725, 2019 04 24.
Article
em En
| MEDLINE
| ID: mdl-30922056
ABSTRACT
Herein we report a highly para-selective C-H olefination of aniline derivatives by a Pd/S,O-ligand-based catalyst. The reaction proceeds under mild reaction conditions with high efficiency and broad substrate scope, including mono-, di-, and trisubstituted tertiary, secondary, and primary anilines. The S,O-ligand is responsible for the dramatic improvements in substrate scope and the high para-selectivity observed. This methodology is operationally simple, scalable, and can be performed under aerobic conditions.
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MEDLINE
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En
Ano de publicação:
2019
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Article